PMID- 8055622
OWN - NLM
STAT- MEDLINE
DCOM- 19940915
LR  - 20190512
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 15
IP  - 8
DP  - 1994 Aug
TI  - Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and 
      transforming growth factor beta during liver tumor promotion with phenobarbital.
PG  - 1473-8
AB  - Chronic exposure of rats to the liver tumor promoter phenobarbital (PB) 
      significantly reduces the ability of normal hepatocytes, but not of initiated 
      hepatocytes, to respond to mitogenic stimuli. This reduced proliferative ability 
      of normal hepatocytes was correlated with a marked elevation in hepatic 
      concentration of the potent mito-inhibitory factor, transforming growth 
      factor-beta 1 (TGF-beta 1). PB also increased the mannose 
      6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor concentration in 
      hepatocytes, with a concomitant up-regulation in gene expression. Since the 
      M6P/IGF-II receptor facilitates the proteolytic activation of TGF-beta 1, this 
      suggests that PB increases the capacity of normal hepatocytes to activate 
      TGF-beta 1. In contrast, a subset of preneoplastic lesions induced with 
      N-nitrosodiethylamine did not demonstrate elevated levels of the M6P/IGF-II 
      receptor or TGF-beta 1 in response to PB. These findings emphasize the potential 
      importance of TGF-beta 1 during liver tumor promotion with PB and suggest that 
      reduction of M6P/IGF-II receptor levels in liver tumors may provide the tumor 
      cells with an important selective growth advantage.
FAU - Jirtle, R L
AU  - Jirtle RL
AD  - Department of Radiation Oncology, Duke University Medical Center, Durham, NC 
      27710.
FAU - Hankins, G R
AU  - Hankins GR
FAU - Reisenbichler, H
AU  - Reisenbichler H
FAU - Boyer, I J
AU  - Boyer IJ
LA  - eng
GR  - NCI CA25951/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, IGF Type 2)
RN  - 0 (Transforming Growth Factor beta)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Liver/chemistry/drug effects
MH  - Liver Neoplasms, Experimental/chemically induced/*metabolism
MH  - Male
MH  - Phenobarbital/*toxicity
MH  - Precancerous Conditions/chemically induced/*metabolism
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptor, IGF Type 2/*analysis/genetics
MH  - Transforming Growth Factor beta/*analysis/genetics
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1093/carcin/15.8.1473 [doi]
PST - ppublish
SO  - Carcinogenesis. 1994 Aug;15(8):1473-8. doi: 10.1093/carcin/15.8.1473.