PMID- 8055706
OWN - NLM
STAT- MEDLINE
DCOM- 19940914
LR  - 20220311
IS  - 0011-4529 (Print)
IS  - 0011-4529 (Linking)
VI  - 77
IP  - 311
DP  - 1994
TI  - In vitro vitamin E and selenium supplementation improves neutrophil-mediated 
      functions and monocyte chemoattractant protein-1 production in the elderly.
PG  - 225-32
AB  - The in vitro effects of vitamin E and selenium on either polymorphonuclear cell 
      (PMN)-mediated chemotaxis and phagocytosis or monocyte chemoattractant protein-1 
      (MCP-1) production in 21 well-nourished elderly donors were evaluated. Results 
      show that, before treatment, old subjects were characterized by a decrease of 
      both PMN functions and cytokine (CK) release. By contrast, in vitro vitamin E and 
      selenium supplementation was able to enhance significantly the depressed PMN 
      activities and MCP-1 synthesis. These findings suggest a role for both nutrients 
      in the modulation of impaired phagocyte responsiveness during senescence.
FAU - Ventura, M T
AU  - Ventura MT
AD  - Istituto di Medicina Clinica, University of Bari Medical Faculty, Italy.
FAU - Serlenga, E
AU  - Serlenga E
FAU - Tortorella, C
AU  - Tortorella C
FAU - Antonaci, S
AU  - Antonaci S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytobios
JT  - Cytobios
JID - 0207227
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 1406-18-4 (Vitamin E)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cells, Cultured
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*biosynthesis
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Neutrophils/cytology/*drug effects/physiology
MH  - Phagocytosis/drug effects
MH  - Selenium/*pharmacology
MH  - Vitamin E/*pharmacology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Cytobios. 1994;77(311):225-32.