PMID- 8057662
OWN - NLM
STAT- MEDLINE
DCOM- 19940912
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 8
IP  - 8
DP  - 1994 Aug
TI  - Deletion of the retinoblastoma gene in multiple myeloma.
PG  - 1280-4
AB  - Deletion of the retinoblastoma gene (Rb-1) was found in more than 50% (12/23) of 
      patients with multiple myeloma (MM) by fluorescence in situ hybridization (FISH). 
      Myeloma cells were highly purified from bone marrow aspirates by flow cytometry 
      and analyzed using probes specific for the Rb-1 gene and the centromeric region 
      of chromosomes 13 and 21. Routine cytogenetics revealed abnormal chromosome 13 in 
      only 17% (4/23) of these patients. No correlation between Rb-1 deletion and tumor 
      stage, immunoglobulin isotype, anemia, serum beta-2 microglobulin levels, patient 
      age or the extent of prior therapy was found. However, the high incidence of Rb-1 
      deletion detected by FISH suggests a role of this tumor suppressor gene in the 
      biology of MM. Although allelic loss of the Rb-1 gene is unlikely to be the only 
      genetic change necessary for the development of MM, it may be a relatively early 
      event in MM unrelated to chemotherapeutic intervention. Since the Rb-1 gene 
      suppresses IL-6 production and secretion, Rb-1 deletion may result in 
      deregulation of IL-6 expression and hence expansion of IL-6 dependent myeloma 
      clones.
FAU - Dao, D D
AU  - Dao DD
AD  - Department of Medicine, University of Arkansas for Medical Sciences, Little Rock.
FAU - Sawyer, J R
AU  - Sawyer JR
FAU - Epstein, J
AU  - Epstein J
FAU - Hoover, R G
AU  - Hoover RG
FAU - Barlogie, B
AU  - Barlogie B
FAU - Tricot, G
AU  - Tricot G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Interleukin-1)
SB  - IM
GS  - Rb-1
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow/pathology
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 13
MH  - *Chromosomes, Human, Pair 21
MH  - Cosmids
MH  - DNA, Neoplasm/analysis
MH  - Exons
MH  - Female
MH  - *Gene Deletion
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes, Retinoblastoma
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interleukin-1/biosynthesis
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1994 Aug;8(8):1280-4.