PMID- 8059327
OWN - NLM
STAT- MEDLINE
DCOM- 19940915
LR  - 20190821
IS  - 0090-3019 (Print)
IS  - 0090-3019 (Linking)
VI  - 41
IP  - 6
DP  - 1994 Jun
TI  - Complete regression of anaplastic astrocytoma by intravenous tumor necrosis 
      factor-alpha (TNF alpha) after recurrence: a case report.
PG  - 482-5
AB  - A 61-year-old male patient had a recurrence of anaplastic astrocytoma after 
      initial chemoradiotherapy. After histologic confirmation of the recurrent tumor, 
      he was treated with intravenous administration of human natural tumor necrosis 
      factor-alpha (TNF alpha). Morphometric analysis of the tumor volumes demonstrated 
      that the tumor continued to regress for 8 months during the course of intravenous 
      TNF alpha therapy, and finally disappeared (total dose of intravenous TNF alpha, 
      785,000 JRU). The regression of tumor paralleled the neurologic improvement. He 
      has had no signs of recurrence for 2 years. The present experience indicates that 
      at least a certain population of malignant gliomas can be successfully treated by 
      a systemic administration of TNF alpha without a major adverse effect.
FAU - Maruno, M
AU  - Maruno M
AD  - Department of Neurosurgery, Osaka University Medical School, Japan.
FAU - Yoshimine, T
AU  - Yoshimine T
FAU - Nakata, H
AU  - Nakata H
FAU - Nishioka, K
AU  - Nishioka K
FAU - Kato, A
AU  - Kato A
FAU - Hayakawa, T
AU  - Hayakawa T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Surg Neurol
JT  - Surgical neurology
JID - 0367070
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Brain/pathology
MH  - Brain Neoplasms/pathology/*therapy
MH  - Glioblastoma/pathology/*therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/pathology/*therapy
MH  - Remission Induction
MH  - Tumor Necrosis Factor-alpha/adverse effects/*therapeutic use
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 0090-3019(94)90012-4 [pii]
AID - 10.1016/0090-3019(94)90012-4 [doi]
PST - ppublish
SO  - Surg Neurol. 1994 Jun;41(6):482-5. doi: 10.1016/0090-3019(94)90012-4.