PMID- 8059727
OWN - NLM
STAT- MEDLINE
DCOM- 19940915
LR  - 20220311
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 74
IP  - 5
DP  - 1994 Sep 1
TI  - Blood levels of erythropoietin in congestive heart failure and correlation with 
      clinical, hemodynamic, and hormonal profiles.
PG  - 468-73
AB  - Plasma levels of erythropoietin (mU/ml) were measured in patients with congestive 
      heart failure (CHF) (n = 108) and in a control group of normal subjects (n = 45). 
      In normal subjects, plasma levels of erythropoietin were 1.9 +/- 0.2. In patients 
      with CHF, plasma levels of erythropoietin increased progressively according to 
      New York Heart Association (NYHA) class (I: 1.4 +/- 0.2, n = 28; II: 5.4 +/- 0.8, 
      n = 27; III: 9.6 +/- 2, n = 32; IV: 34 +/- 8, n = 21; F = 57.7, p < 0.001) and 
      were significantly higher in NYHA classes II, III, and IV than in normal 
      subjects. Plasma erythropoietin significantly decreased (from 43 +/- 14 to 12 +/- 
      3 mU/ml, p < 0.01) in patients with severe CHF (n = 9) when enalapril (20 mg/day 
      administered orally) was added to long-term treatment for 3 weeks. Finally, in a 
      subgroup of patients with NYHA class IV CHF (n = 9) and high plasma 
      erythropoietin levels (37 +/- 9 mU/ml), packed red blood cell volume, assessed by 
      the iodine-125-albumin dilution method, was higher than that in normal subjects 
      (n = 11) (2,616 +/- 235 vs 2,028 +/- 119 ml, p < 0.05). The present study 
      demonstrates that plasma erythropoietin levels are elevated in a large cohort of 
      patients with CHF of varying etiology, and that this increase is related to the 
      progression of the disease. The increase in circulating erythropoietin is 
      associated with augmented packed red blood cell volume in patients with severe 
      CHF. These results suggest a participation of erythropoietin in the complex 
      neurohormonal response that occurs in CHF.
FAU - Volpe, M
AU  - Volpe M
AD  - Department of Internal Medicine, School of Medicine, University of Napoli 
      Federico II, Naples, Italy.
FAU - Tritto, C
AU  - Tritto C
FAU - Testa, U
AU  - Testa U
FAU - Rao, M A
AU  - Rao MA
FAU - Martucci, R
AU  - Martucci R
FAU - Mirante, A
AU  - Mirante A
FAU - Enea, I
AU  - Enea I
FAU - Russo, R
AU  - Russo R
FAU - Rubattu, S
AU  - Rubattu S
FAU - Condorelli, G L
AU  - Condorelli GL
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Hormones)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Erythropoietin/*blood
MH  - Female
MH  - Heart Failure/*blood/etiology/physiopathology
MH  - Hemodynamics/*physiology
MH  - Hormones/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Severity of Illness Index
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0002-9149(94)90905-9 [pii]
AID - 10.1016/0002-9149(94)90905-9 [doi]
PST - ppublish
SO  - Am J Cardiol. 1994 Sep 1;74(5):468-73. doi: 10.1016/0002-9149(94)90905-9.