PMID- 8062023
OWN - NLM
STAT- MEDLINE
DCOM- 19940920
LR  - 20060424
IS  - 1055-8586 (Print)
IS  - 1055-8586 (Linking)
VI  - 2
IP  - 1
DP  - 1993 Feb
TI  - Wilms' tumor: diagnosis and treatment in the 1990s.
PG  - 59-68
AB  - The present therapy of Wilms' tumor is a classic example of the modern 
      multidisciplinary treatment of childhood malignancies, and the organization of 
      the National Wilms' Tumor Studies (NWTS) has served as a prototype for other 
      collaborative studies of childhood tumors. More than 80% of all children with 
      Wilms' tumor can now be expected to have a long term relapse free survival. The 
      NWTS is in large part responsible for this excellent outlook and continues its 
      emphasis on decreasing the morbidity of therapy without sacrificing relapse free 
      survival by tailoring therapy based on histology and accurate surgical staging. 
      The pathological classification of Wilms' and its effect on therapy and prognosis 
      is now being used as a guide in the study of other childhood malignancies. The 
      surgeon continues to play a key role in the multimodality management of the child 
      with a Wilms' tumor since subsequent therapy will be determined by the extent of 
      the tumor at the time of operation. The identification of histological type, the 
      presence or absence of residual tumor within the abdomen following resection, and 
      the status of lymph node metastases are of utmost importance. Advances in 
      cytogenetics and refinement of histopathologic staging will allow the pediatric 
      surgical oncologist, pediatric oncologist, and pediatric radiation therapist to 
      continue to modify therapy for specific patient groups in the future.
FAU - Shochat, S J
AU  - Shochat SJ
AD  - Division of Pediatric Surgery, Stanford University School of Medicine, CA 
      94305-5116.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Pediatr Surg
JT  - Seminars in pediatric surgery
JID - 9216162
SB  - IM
MH  - Adolescent
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Chemotherapy, Adjuvant
MH  - Child
MH  - Child, Preschool
MH  - Diagnostic Imaging
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/drug therapy/pathology/radiotherapy/*surgery
MH  - Male
MH  - Neoplasm Staging
MH  - Radiotherapy Dosage
MH  - Wilms Tumor/drug therapy/pathology/radiotherapy/*surgery
RF  - 46
EDAT- 1993/02/01 00:00
MHDA- 1993/02/01 00:01
CRDT- 1993/02/01 00:00
PHST- 1993/02/01 00:00 [pubmed]
PHST- 1993/02/01 00:01 [medline]
PHST- 1993/02/01 00:00 [entrez]
PST - ppublish
SO  - Semin Pediatr Surg. 1993 Feb;2(1):59-68.