PMID- 806227
OWN - NLM
STAT- MEDLINE
DCOM- 19750909
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 58
IP  - 6
DP  - 1975 Jun
TI  - Studies of immunoglobulins, bentonite flocculation and IgE, IgG and IgM 
      antibodies in serum from patients with trichinosis.
PG  - 787-93
AB  - Serial serum samples were obtained from two patients from a family of four who 
      ingested raw pork at a known time and in whom trichinosis developed. Single and 
      occasionally two serum samples were obtained from other patients with proved 
      trichinosis. Studies of these serum samples showed that elevations of serum 
      immunoglobulin E (IgE) levels do occur but not in all serum samples and that even 
      when these levels are elevated, they are not high enough to be of diagnostic 
      value. This is also true for serum immunoglobulin M (IgM). Using a solid phase 
      radioimmunoadsorbent test, IgE, IgG and IgM antibodies were detected in the 
      serums. The IgE antibody activity appeared early but was not present in all 
      samples. The IgM antibody activity appeared later than the IgE and IgG antibody 
      activity, and there was a statistically significant correlation between IgM 
      antibodies as determined by radioimmunoassay and the bentonite flocculation 
      titers suggesting that the bentonite flocculation is due to IgM antibody. IgM 
      antibodies detected by radioimmunoassay were positive in all serum samples from 
      patients with trichinosis except for a sample obtained 3 days after the onset of 
      symptoms. The early increase in IgG antibodies and the occurrence of these 
      antibodies in all serum samples obtained more than 3 days after onset of symptoms 
      suggest a potential diagnostic use if serial samples are available early in the 
      course of the disease.
FAU - Patterson, R
AU  - Patterson R
FAU - Roberts, M
AU  - Roberts M
FAU - Slonka, G
AU  - Slonka G
FAU - McAninch, J
AU  - McAninch J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Immunoglobulins)
RN  - 0 (Iodine Radioisotopes)
RN  - 1302-78-9 (Bentonite)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Bentonite
MH  - Flocculation Tests
MH  - Humans
MH  - Immunodiffusion
MH  - Immunoglobulin E/analysis
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - *Immunoglobulins/analysis
MH  - Iodine Radioisotopes
MH  - Radioimmunoassay
MH  - Time Factors
MH  - Trichinellosis/blood/diagnosis/*immunology
EDAT- 1975/06/01 00:00
MHDA- 1975/06/01 00:01
CRDT- 1975/06/01 00:00
PHST- 1975/06/01 00:00 [pubmed]
PHST- 1975/06/01 00:01 [medline]
PHST- 1975/06/01 00:00 [entrez]
AID - 0002-9343(75)90633-6 [pii]
AID - 10.1016/0002-9343(75)90633-6 [doi]
PST - ppublish
SO  - Am J Med. 1975 Jun;58(6):787-93. doi: 10.1016/0002-9343(75)90633-6.