PMID- 8067260
OWN - NLM
STAT- MEDLINE
DCOM- 19940919
LR  - 20171116
IS  - 0001-6837 (Print)
IS  - 0001-6837 (Linking)
VI  - 50
IP  - 6
DP  - 1993
TI  - Effect of Tolpa Peat Preparation on some immune parameters in healthy volunteers. 
      Preliminary data.
PG  - 481-9
AB  - Investigations of some immune parameters were carried out in healthy humans 
      receiving TPP in doses of 50, 100, 300 and 600 mg daily for 14 days. The percent 
      and composition of T lymphocyte subsets were studied along with the ability to 
      generate interleukin-1 (Il-1) and interleukin-2 (Il-2) as well as spontaneous and 
      PHA stimulated expression of receptors for Il-2 (TAC) and transferrin receptor 
      (Tr) on lymphocytes. Lymphocytes proliferation induced with mitogens and 
      alloantigens, generation of both Tumour Necrosis Factor alpha(TNF alpha) by 
      monocytes and superoxide radicals by granulocytes were estimated. A 50 mg dose of 
      TPP changed neither the T-cell percent among mononuclear cells nor the 
      composition of T-cell subsets. A higher dosage of 100 mg of TPP caused a 
      significant increase of the percent of T-cells on the 14th day but did not 
      influence their subset composition. On the 14th and 28th day of the observation a 
      statistically insignificant decrease of IL-2 generation was observed but with no 
      change of both TAC receptor expression on lymphocytes and the ability to generate 
      IL-1 by monocytes. TPP in the doses of 50 and 100 mg exerted a slight 
      immunomodulatory potential in healthy humans, however the immunological 
      parameters assessed were within the standard values. In other immune parameters 
      examined during the administration of higher TPP doses in human groups consisted 
      of four volunteers considerable differences have been found but individual 
      differences in a limited experimental group and the lack of a placebo group did 
      not allow for definite conclusions but for preliminary data only.
FAU - Baj, Z
AU  - Baj Z
AD  - Department of Pathophysiology and Immunology, Institute of Basic Medical 
      Sciences, WAM, Lodz, Poland.
FAU - Zeman, K
AU  - Zeman K
FAU - Sulowska, Z
AU  - Sulowska Z
FAU - Majewska, E
AU  - Majewska E
FAU - Pokoca, L
AU  - Pokoca L
FAU - Kocur, E
AU  - Kocur E
FAU - Kantorski, J
AU  - Kantorski J
FAU - Fornalczyk, E
AU  - Fornalczyk E
FAU - Banasik, M
AU  - Banasik M
FAU - Tchorzewski, H
AU  - Tchorzewski H
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Pol Pharm
JT  - Acta poloniae pharmaceutica
JID - 2985167R
RN  - 0 (Amino Acids)
RN  - 0 (Carbohydrates)
RN  - 0 (Cytokines)
RN  - 0 (Drug Combinations)
RN  - 0 (Humic Substances)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Receptors, Transferrin)
RN  - 0 (Soil)
RN  - 0 (Tolpa)
RN  - 0 (Uronic Acids)
SB  - IM
MH  - Adult
MH  - Amino Acids/*pharmacology
MH  - Carbohydrates/*pharmacology
MH  - Cytokines/*biosynthesis
MH  - Drug Combinations
MH  - Humans
MH  - Humic Substances/*pharmacology
MH  - Lymphocyte Activation/drug effects
MH  - Lymphocyte Subsets/drug effects/*immunology
MH  - Male
MH  - Receptors, Interleukin-2/drug effects
MH  - Receptors, Transferrin/drug effects
MH  - Soil
MH  - Uronic Acids/*pharmacology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Pol Pharm. 1993;50(6):481-9.