PMID- 8069012
OWN - NLM
STAT- MEDLINE
DCOM- 19940929
LR  - 20220409
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 33
IP  - 4
DP  - 1994 Apr
TI  - Effect of daily subcutaneous administration of recombinant erythropoietin on 
      chronic anemia in rheumatoid arthritis.
PG  - 193-7
AB  - Mean (+/- SD) serum erythropoietin (EPO) levels were 18.6 +/- 5.6 mU/ml in 180 
      normal Japanese subjects. Serum EPO levels were elevated with a negative 
      correlation on a log scale (r = -0.864, P < 0.005) to hematocrit (Ht) values in 
      anemic patients not associated with rheumatoid arthritis (RA) or chronic renal 
      failure (CRF). Serum EPO levels in patients with RA (31.6 +/- 16.4 mU/ml) were 
      relatively lower than those in normal subjects and anemic patients without RA or 
      CRF when matched for comparative Ht values. Seven anemic patients with RA were 
      treated by daily subcutaneous (sc) injection of recombinant EPO (rEPO, 500-1,000 
      U/day) for 4 weeks. The patients had initial Ht values of 25.1% or less and 
      maintained stable clinical status. The treatment with rEPO raised serum EPO 
      levels (53.8 +/- 15.2 mU/ml, P < 0.05), which resulted in an increase in Ht 
      values (more than 3%) in 6 out of 7 patients with RA. The mean (+/- SD) Ht values 
      at the end of the treatment with rEPO (500-1,000 U/day) were greater than those 
      before the treatment in the 7 patients with RA (28.5 +/- 4.6 vs. 22.7 +/- 2.5%, P 
      < 0.05). These findings suggest that chronic anemia associated with RA may be 
      corrected by daily sc injection of a small dose of rEPO.
FAU - Kato, Y
AU  - Kato Y
AD  - Department of Medicine, Shimane Medical University, Izumo.
FAU - Takagi, C
AU  - Takagi C
FAU - Tanaka, J
AU  - Tanaka J
FAU - Masaki, Y
AU  - Masaki Y
FAU - Furuya, H
AU  - Furuya H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/complications/*drug therapy
MH  - Arthritis, Rheumatoid/*complications
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Erythropoietin/*administration & dosage/blood/therapeutic use
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Recombinant Proteins/administration & dosage/blood/therapeutic use
MH  - Time Factors
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.2169/internalmedicine.33.193 [doi]
PST - ppublish
SO  - Intern Med. 1994 Apr;33(4):193-7. doi: 10.2169/internalmedicine.33.193.