PMID- 8069253
OWN - NLM
STAT- MEDLINE
DCOM- 19940926
LR  - 20190719
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 17
IP  - 4
DP  - 1994 Apr
TI  - Serum hepatocyte growth factor activity and hepatocyte proliferation in 
      Long-Evans with a cinnamon-like coat color rats with hepatic lesions.
PG  - 486-9
AB  - We classified hepatic lesions spontaneously developed by Long-Evans with a 
      cinnamon-like coat color (LEC) rats into the following four stages: Normal liver, 
      acute hepatitis, chronic hepatitis, and hepatoma, by biochemical tests of the 
      sera, and anatomical and histopathological examination of the livers. Hepatocyte 
      growth factor (HGF) activity in the sera of LEC rats which developed acute 
      hepatitis, chronic hepatitis, and hepatoma was higher than that of normal LEC 
      rats. In particular, HGF activity in the sera of the LEC rats with acute 
      hepatitis was about 70-fold that of normal LEC rats. However, primary cultured 
      hepatocytes of LEC rats with hepatic lesions were hardly proliferated by 
      stimulation with EGF and insulin in vitro or with increased HGF in vivo. These 
      results suggest that the hepatocytes of LEC rats with hepatic lesions disorder 
      the signal transduction of growth factors.
FAU - Tsujikawa, K
AU  - Tsujikawa K
AD  - Faculty of Pharmaceutical Sciences, Osaka University, Japan.
FAU - Suzuki, N
AU  - Suzuki N
FAU - Shimaoka, T
AU  - Shimaoka T
FAU - Tanaka, K
AU  - Tanaka K
FAU - Kohama, Y
AU  - Kohama Y
FAU - Sugiyama, T
AU  - Sugiyama T
FAU - Kimura, M
AU  - Kimura M
FAU - Mimura, T
AU  - Mimura T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Biomarkers/blood
MH  - Carcinoma, Hepatocellular/*blood/pathology
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Chronic Disease
MH  - Hepatitis, Animal/*blood/pathology
MH  - Hepatocyte Growth Factor/*blood/pharmacology
MH  - Insulin/blood/pharmacology
MH  - Liver/cytology/drug effects/*pathology
MH  - Liver Neoplasms/*blood/pathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1248/bpb.17.486 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 1994 Apr;17(4):486-9. doi: 10.1248/bpb.17.486.