PMID- 8074666
OWN - NLM
STAT- MEDLINE
DCOM- 19940929
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 203
IP  - 1
DP  - 1994 Aug 30
TI  - Synergistic differentiation of U937 cells by all-trans retinoic acid and 1 alpha, 
      25-dihydroxyvitamin D3 is associated with the expression of retinoid X receptor 
      alpha.
PG  - 272-80
AB  - Among the nuclear hormone receptors, the retinoid X receptors (RXRs) play a 
      central role through their ability to heterodimerize with other members of this 
      family of transcription factors, including retinoic acid (RA) and vitamin D (VD3) 
      receptors. We have previously found that all-trans retinoic acid and 1 alpha, 
      25-dihydroxyvitamin D3 cooperate to induce monocytic differentiation of U937 
      human leukemic cells. Here the expression of RXR alpha protein in myelomonocytic 
      cells was studied by immunodetection using polyclonal antibodies. RXR alpha was 
      detected upon exposure of cells to VD3 and higher levels were found in cells 
      treated by combinations of RA and VD3 under conditions where both agents 
      synergized for inducing monocytic properties.
FAU - Defacque, H
AU  - Defacque H
AD  - INSERM U65, Universite de Montpellier II, France.
FAU - Commes, T
AU  - Commes T
FAU - Sevilla, C
AU  - Sevilla C
FAU - Rochette-Egly, C
AU  - Rochette-Egly C
FAU - Marti, J
AU  - Marti J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 10028-17-8 (Tritium)
RN  - 5688UTC01R (Tretinoin)
RN  - FXC9231JVH (Calcitriol)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Calcitriol/*pharmacology
MH  - Cell Differentiation/*drug effects/physiology
MH  - Cell Division/drug effects
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - Chlorocebus aethiops
MH  - DNA, Neoplasm/biosynthesis
MH  - Drug Synergism
MH  - Humans
MH  - Kinetics
MH  - Leukemia, Promyelocytic, Acute
MH  - Lymphoma, Large B-Cell, Diffuse
MH  - Receptors, Cytoplasmic and Nuclear/*biosynthesis
MH  - *Receptors, Retinoic Acid
MH  - Retinoid X Receptors
MH  - Thymidine/metabolism
MH  - Time Factors
MH  - *Transcription Factors
MH  - Transfection
MH  - Tretinoin/*pharmacology
MH  - Tritium
MH  - Tumor Cells, Cultured
EDAT- 1994/08/30 00:00
MHDA- 1994/08/30 00:01
CRDT- 1994/08/30 00:00
PHST- 1994/08/30 00:00 [pubmed]
PHST- 1994/08/30 00:01 [medline]
PHST- 1994/08/30 00:00 [entrez]
AID - S0006291X84721784 [pii]
AID - 10.1006/bbrc.1994.2178 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1994 Aug 30;203(1):272-80. doi: 
      10.1006/bbrc.1994.2178.