PMID- 8075863
OWN - NLM
STAT- MEDLINE
DCOM- 19941005
LR  - 20190512
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 112
IP  - 2
DP  - 1994 Jun
TI  - Increase of extracellular brain calcium involved in interleukin-1 beta-induced 
      pyresis in the rabbit: antagonism by dexamethasone.
PG  - 449-52
AB  - 1. This study investigates the role of extracellular brain calcium in the 
      hyperthermia induced by interleukin-1 beta (IL-1 beta). 2. 
      Intracerebroventricular (i.c.v.) injection of IL-1 beta (12.5 ng kg-1) in rabbits 
      caused a prompt and sustained rise in cerebrospinal fluid (CSF) Ca2+ 
      concentration ([Ca2+]) followed by enhanced prostaglandin E2 (PGE2) release and 
      hyperthermia. 3. A linear and significant correlation was observed between the 
      increase in [Ca2+] induced by IL-1 beta and the rise in body temperature. 4. 
      Ventriculo-cisternal perfusion with artificial CSF containing the calcium 
      chelator EGTA (1.3 mM) blocked the IL-1-induced PGE2 release and countered the 
      febrile response. 5. I.c.v. administration of dexamethasone (Dex) (2.4 and 24 
      micrograms kg-1) 100 min prior to IL-1 beta, dose-dependently antagonized the 
      cytokine-induced Ca2+ increase, the PGE2 release and the febrile response. 6. 
      These results suggest that changes in extracellular brain calcium are involved in 
      the regulation of body temperature. In this light, the antipyretic action of Dex 
      may be related to its effect on Ca2+ uptake.
FAU - Palmi, M
AU  - Palmi M
AD  - Istituto di Scienze Farmacologiche, Universita di Siena, Italy.
FAU - Frosini, M
AU  - Frosini M
FAU - Becherucci, C
AU  - Becherucci C
FAU - Sgaragli, G P
AU  - Sgaragli GP
FAU - Parente, L
AU  - Parente L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Interleukin-1)
RN  - 526U7A2651 (Egtazic Acid)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Body Temperature Regulation/*drug effects
MH  - Brain Chemistry/drug effects/*physiology
MH  - Calcium/cerebrospinal fluid/*physiology
MH  - Dexamethasone/administration & dosage/*pharmacology
MH  - Dinoprostone/biosynthesis
MH  - Egtazic Acid/pharmacology
MH  - Extracellular Space/metabolism/*physiology
MH  - Injections, Intraventricular
MH  - Interleukin-1/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Male
MH  - Rabbits
PMC - PMC1910332
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
PMCR- 1995/06/01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PHST- 1995/06/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1994.tb13093.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1994 Jun;112(2):449-52. doi: 10.1111/j.1476-5381.1994.tb13093.x.