PMID- 8076341
OWN - NLM
STAT- MEDLINE
DCOM- 19941004
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 76
IP  - 1
DP  - 1994 Aug
TI  - Supernumerary ring chromosomes containing chromosome 17 sequences. A specific 
      feature of dermatofibrosarcoma protuberans?
PG  - 1-9
AB  - Mystery surrounds the mechanisms by which the uncommon cutaneous tumor 
      dermatofibrosarcoma protuberans (DP) arises and progresses. A clue may be at hand 
      in the form of extra abnormal chromosomes (one of three ring chromosomes per case 
      with or without other chromosome abnormalities) seen in some 10 cases, including 
      five cases in our experience. The specificity of the rings to DP would be 
      enhanced if the rings were found to contain a contribution from a constant 
      chromosome. We here report fluorescence in situ hybridization (FISH) results 
      bearing on the chromosomal content of DP rings, together with clinical, 
      pathologic, and cytogenetic documentation of our first two cases, which were 
      briefly reported earlier, and three new DP cases. To dissect a translocation (in 
      our 2nd case), we probed by FISH and discovered chromosome 17 sequences in the 
      rings in all five DP cases. Nonfluorescent bands were seen on some rings painted 
      with a whole chromosome 17 probe, indicating the presence in these rings of 
      foreign chromosome sequences. The complexity of the rings was underscored by the 
      detection in only one case of chromosome 17 centromeric sequences. The situation 
      in DP seems to have parallels to that in well-differentiated liposarcoma, another 
      tumor of intermediate malignancy with extra abnormal marker chromosome containing 
      contributions from a constant chromosome and variable donors. In DP the 
      supernumerary rings are clearly specific and significant.
FAU - Pedeutour, F
AU  - Pedeutour F
AD  - Laboratoire de Genetique Moleculaire des Cancers Humains, URA CNRS, Nice, France.
FAU - Coindre, J M
AU  - Coindre JM
FAU - Sozzi, G
AU  - Sozzi G
FAU - Nicolo, G
AU  - Nicolo G
FAU - Leroux, A
AU  - Leroux A
FAU - Toma, S
AU  - Toma S
FAU - Miozzo, M
AU  - Miozzo M
FAU - Bouchot, C
AU  - Bouchot C
FAU - Hecht, F
AU  - Hecht F
FAU - Ayraud, N
AU  - Ayraud N
AU  - et al.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cells, Cultured
MH  - *Chromosomes, Human, Pair 17
MH  - Dermatofibrosarcoma/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - *Ring Chromosomes
MH  - Skin Neoplasms/*genetics
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 0165-4608(94)90060-4 [pii]
AID - 10.1016/0165-4608(94)90060-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Aug;76(1):1-9. doi: 10.1016/0165-4608(94)90060-4.