PMID- 8077695
OWN - NLM
STAT- MEDLINE
DCOM- 19941005
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 103
IP  - 3
DP  - 1994 Sep
TI  - Hepatocyte growth factor/scatter factor stimulates hair growth of mouse vibrissae 
      in organ culture.
PG  - 306-9
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional polypeptide 
      that acts as a mitogen, motogen, or morphogen, depending on the biologic context. 
      In this study, we examined the effect of HGF/SF on hair growth using a serum-free 
      organ culture system. Vibrissal hair follicles isolated from newborn mice were 
      cultured at 31 degrees C in 95% O2/5% CO2 for 72 h in the presence of various 
      cytokines or growth factors, and elongation of hair shaft, DNA, and protein 
      synthesis in hair follicles were measured. Among the agents tested, only HGF/SF 
      significantly increased hair follicle length (p < 0.001), 3H-thymidine (p < 
      0.001), and 35S-cysteine (p < 0.05) incorporation. The effect of HGF/SF was dose 
      dependent, with maximal stimulation obtained at 10 ng/ml. The increase in hair 
      follicle length and thymidine incorporation were specifically inhibited by a 
      neutralizing antibody against HGF/SF. These results indicate that HGF/SF can 
      promote hair growth and may have clinical utility in this regard.
FAU - Jindo, T
AU  - Jindo T
AD  - Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Tsuboi, R
AU  - Tsuboi R
FAU - Imai, R
AU  - Imai R
FAU - Takamori, K
AU  - Takamori K
FAU - Rubin, J S
AU  - Rubin JS
FAU - Ogawa, H
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cytokines/pharmacology
MH  - DNA/biosynthesis
MH  - Dose-Response Relationship, Drug
MH  - Growth Substances/pharmacology
MH  - Hair/drug effects/*growth & development/metabolism
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Organ Culture Techniques
MH  - Vibrissae/drug effects/*growth & development
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - S0022-202X(94)92164-4 [pii]
AID - 10.1111/1523-1747.ep12394731 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1994 Sep;103(3):306-9. doi: 10.1111/1523-1747.ep12394731.