PMID- 8077726
OWN - NLM
STAT- MEDLINE
DCOM- 19941006
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 3
DP  - 1994 Sep
TI  - C-reactive protein and interleukin-6 are elevated in onchocerciasis patients 
      after ivermectin treatment.
PG  - 663-8
AB  - Ivermectin treatment of onchocerciasis can induce adverse reactions. Mechanisms 
      underlying these reactions are poorly understood but may include activation of 
      neutrophils. This study investigated the acute-phase response in onchocerciasis 
      patients during 2 days after ivermectin treatment. The acute-phase protein 
      C-reactive protein (CRP) and cytokines that mediate the acute-phase response 
      (tumor necrosis factor-alpha [TNF alpha] and interleukin-6 [IL-6]) were measured 
      in 144 skin snip-positive onchocerciasis patients and 12 skin snip-negative 
      controls who received one dose of ivermectin (150 micrograms/kg). No elevated TNF 
      alpha levels were found, but IL-6 and CRP were elevated in 25.7% and 50.7% of the 
      patients, respectively, after ivermectin treatment. Most patients (89.2%) with 
      raised IL-6 also had raised CRP. Such increases were not observed in controls and 
      in patients were correlated with adverse reactions and microfilarial densities. 
      These findings suggest a possible role of the acute-phase response in 
      microfilarial destruction following ivermectin treatment.
FAU - Njoo, F L
AU  - Njoo FL
AD  - Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, 
      Amsterdam.
FAU - Hack, C E
AU  - Hack CE
FAU - Oosting, J
AU  - Oosting J
FAU - Luyendijk, L
AU  - Luyendijk L
FAU - Stilma, J S
AU  - Stilma JS
FAU - Kijlstra, A
AU  - Kijlstra A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 70288-86-7 (Ivermectin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunodiffusion
MH  - Interleukin-6/*blood
MH  - Ivermectin/adverse effects/*therapeutic use
MH  - Onchocerciasis/*blood/*drug therapy/physiopathology
MH  - Reference Values
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/analysis/metabolism
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1093/infdis/170.3.663 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Sep;170(3):663-8. doi: 10.1093/infdis/170.3.663.