PMID- 8078070
OWN - NLM
STAT- MEDLINE
DCOM- 19941004
LR  - 20190710
IS  - 0022-2836 (Print)
IS  - 0022-2836 (Linking)
VI  - 242
IP  - 1
DP  - 1994 Sep 9
TI  - The promoter of the H1zero histone gene contains a DNA element bound by retinoic 
      acid receptors.
PG  - 37-44
AB  - Retinoic-acid mediated differentiation of F9 cells is accompanied by an increased 
      transcription of the histone H1zero gene. This increase is an early response 
      after addition of retinoic acid, suggesting a direct effect of the hormone on 
      transcription of the gene. We show now that the promoter of histone H1zero 
      contains a DNA element, localized 531 base-pairs upstream of the cap site, that 
      is composed of a direct repeat of the sequence PuGGTCA separated by eight 
      base-pairs. This element confers retinoic acid responsiveness to a heterologous 
      thymidine kinase promoter in F9 and HeLa cells. Furthermore, the element forms 
      retarded complexes not only with bacterially expressed retinoic acid receptors 
      (RARs) and retinoid X receptors (RXRs), but also with endogenous F9 receptors. 
      Our results suggest therefore that retinoic acid receptors can control the 
      expression of a chromatin structural gene the expression of which is associated 
      with a differentiated phenotype.
FAU - Mader, S
AU  - Mader S
AD  - Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France.
FAU - Thiele, K
AU  - Thiele K
FAU - Breuer, B
AU  - Breuer B
FAU - Alonso, A
AU  - Alonso A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Mol Biol
JT  - Journal of molecular biology
JID - 2985088R
RN  - 0 (Histones)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Gene Expression Regulation
MH  - HeLa Cells
MH  - Histones/*genetics
MH  - Humans
MH  - In Vitro Techniques
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/metabolism
MH  - Oligodeoxyribonucleotides/chemistry
MH  - *Promoter Regions, Genetic
MH  - Receptors, Retinoic Acid/*metabolism
MH  - Regulatory Sequences, Nucleic Acid
MH  - Transcription, Genetic
EDAT- 1994/09/09 00:00
MHDA- 1994/09/09 00:01
CRDT- 1994/09/09 00:00
PHST- 1994/09/09 00:00 [pubmed]
PHST- 1994/09/09 00:01 [medline]
PHST- 1994/09/09 00:00 [entrez]
AID - S0022283684715555 [pii]
AID - 10.1006/jmbi.1994.1555 [doi]
PST - ppublish
SO  - J Mol Biol. 1994 Sep 9;242(1):37-44. doi: 10.1006/jmbi.1994.1555.