PMID- 8081873
OWN - NLM
STAT- MEDLINE
DCOM- 19941010
LR  - 20191101
IS  - 1061-5385 (Print)
IS  - 1023-7046 (Linking)
VI  - 1
IP  - 2
DP  - 1993 Sep
TI  - Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene.
PG  - 101-11
AB  - The cytokine termed hepatocyte growth factor or scatter factor (HGF/SF) has been 
      implicated in embryonic development and liver regeneration. Mouse HGF/SF cDNA 
      clones were obtained by screening a mouse liver cDNA library with synthetic 
      oligonucleotides, as well as by using the method of reverse 
      transcription-polymerase chain reaction (RT-PCR) with mRNA isolated from adult 
      mouse brain. Sequence analysis of mouse HGF/SF cDNA clones spanning the entire 
      coding region revealed an overall amino acid identity of 90% and 98% with human 
      and rat HGF, respectively. Using mouse HGF antisense RNA as a probe, we observed 
      the expression of HGF/SF mRNA in the liver, kidney, whole brain and cerebellum of 
      adult mice as well as in day 9 and day 10 mouse embryos. The mouse HGF/SF cDNA 
      was utilized for mapping Hgf to the centromeric region of mouse Chromosome 5 in 
      apparent close proximity to the reeler mutation by the analysis of two multilocus 
      crosses. The relationship of Hgf to the reeler mutation is discussed. The 
      availability of mouse HGF/SF cDNA clones should facilitate further analysis of 
      HGF/SF function during development.
FAU - Lee, C C
AU  - Lee CC
AD  - Laboratory of Developmental Biology, National Institute of Dental Research, NIH, 
      Bethesda, MD 20892.
FAU - Kozak, C A
AU  - Kozak CA
FAU - Yamada, K M
AU  - Yamada KM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cell Adhes Commun
JT  - Cell adhesion and communication
JID - 9417027
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
GS  - HGF/SF
GS  - Hgf
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - DNA, Complementary/genetics
MH  - Embryo, Mammalian/metabolism
MH  - Gene Expression
MH  - Hepatocyte Growth Factor/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Ribonucleases
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Tissue Distribution
EDAT- 1993/09/01 00:00
MHDA- 1993/09/01 00:01
CRDT- 1993/09/01 00:00
PHST- 1993/09/01 00:00 [pubmed]
PHST- 1993/09/01 00:01 [medline]
PHST- 1993/09/01 00:00 [entrez]
AID - 10.3109/15419069309095686 [doi]
PST - ppublish
SO  - Cell Adhes Commun. 1993 Sep;1(2):101-11. doi: 10.3109/15419069309095686.