PMID- 8081883
OWN - NLM
STAT- MEDLINE
DCOM- 19941010
LR  - 20191101
IS  - 1061-5385 (Print)
IS  - 1023-7046 (Linking)
VI  - 1
IP  - 4
DP  - 1994 Jan
TI  - Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte 
      growth factor and epidermal growth factor in human carcinoma cells.
PG  - 295-305
AB  - The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal 
      growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was 
      studied. HGF/SF induced scattering of colonic adenocarcinoma HT29 and gastric 
      adenocarcinomas MKN7 and MKN74 cells. Likewise, EGF induced scattering of HT29 
      and MKN7 cells. These cells expressed E-cadherin, which was concentrated at 
      cell-cell contact sites. When the scattering of these cells was induced by HGF/SF 
      or EGF, the E-cadherin concentration at cell-cell boundaries tended to decrease. 
      Immunoblotting analyses, however, demonstrated that these growth factor 
      treatments did not alter the expression of E-cadherin and E-cadherin-associated 
      proteins, alpha- and beta-catenin and plakoglobin. beta-Catenin, plakoglobin and 
      an unidentified 115-kDa molecule associated with E-cadherin were found to be 
      phosphorylated at tyrosine residues, and these phosphorylations were enhanced by 
      the growth factor treatments. These results suggest that HGF/SF and EGF may 
      modulate the function of the cadherin-catenin system via tyrosine phosphorylation 
      of cadherin-associated proteins.
FAU - Shibamoto, S
AU  - Shibamoto S
AD  - Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan 
      University, Osaka, Japan.
FAU - Hayakawa, M
AU  - Hayakawa M
FAU - Takeuchi, K
AU  - Takeuchi K
FAU - Hori, T
AU  - Hori T
FAU - Oku, N
AU  - Oku N
FAU - Miyazawa, K
AU  - Miyazawa K
FAU - Kitamura, N
AU  - Kitamura N
FAU - Takeichi, M
AU  - Takeichi M
FAU - Ito, F
AU  - Ito F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cell Adhes Commun
JT  - Cell adhesion and communication
JID - 9417027
RN  - 0 (CTNNA1 protein, human)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Desmoplakins)
RN  - 0 (Trans-Activators)
RN  - 0 (alpha Catenin)
RN  - 0 (beta Catenin)
RN  - 0 (gamma Catenin)
RN  - 42HK56048U (Tyrosine)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Cadherins/metabolism
MH  - Cell Adhesion/drug effects/physiology
MH  - Cytoskeletal Proteins/*metabolism
MH  - Desmoplakins
MH  - Epidermal Growth Factor/*pharmacology
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Humans
MH  - Neoplasm Invasiveness/physiopathology
MH  - Phosphorylation
MH  - *Trans-Activators
MH  - Tumor Cells, Cultured/drug effects/metabolism
MH  - Tyrosine/metabolism
MH  - alpha Catenin
MH  - beta Catenin
MH  - gamma Catenin
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.3109/15419069409097261 [doi]
PST - ppublish
SO  - Cell Adhes Commun. 1994 Jan;1(4):295-305. doi: 10.3109/15419069409097261.