PMID- 8085247
OWN - NLM
STAT- MEDLINE
DCOM- 19941013
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 74
IP  - 5
DP  - 1994 Jun 1
TI  - Prevention of thrombus formation and growth by antithrombin III and heparin 
      cofactor II-dependent thrombin inhibitors: importance of heparin cofactor II.
PG  - 463-75
AB  - Heparin (HEP) prevents thrombus formation (TF) and thrombus growth (TG), by 
      accelerating thrombin (THR) inhibition by antithrombin III (ATIII). Recent 
      studies suggest that dermatan sulphate which catalyzes thrombin inhibition by 
      heparin cofactor II (HCII), can inhibit TF and TG as effectively as HEP. This 
      study compared the antithrombotic effects of HEP and another agent, Sulodexide 
      (SLX) which catalyzes thrombin inhibition by ATIII and HCII simultaneously. TF 
      was induced in rabbit jugular veins, using the stasis/hypercoagulation model. TG 
      was measured as the accretion of 125I-fibrin onto existing thrombi in rabbit 
      jugular veins. HEP and SLX inhibited TF when given in doses of 10 and 5 
      anti-thrombin U/kg, respectively. SLX (16 anti-thrombin U/kg or 260 
      micrograms/kg) was more effective than HEP (120 anti-thrombin U/kg or 800 
      micrograms/kg) in preventing TG when administered either as a bolus or by 
      continuous infusion. These data suggest that agents which accelerate THR 
      inhibition by both ATIII and HCII simultaneously, can inhibit TF and TG with less 
      systemic anticoagulation than comparable antithrombotic doses of HEP.
FAU - Buchanan, M R
AU  - Buchanan MR
AD  - McMaster University, Dept of Surgery, Hamilton, Ontario, Canada.
FAU - Liao, P
AU  - Liao P
FAU - Smith, L J
AU  - Smith LJ
FAU - Ofosu, F A
AU  - Ofosu FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Glycosaminoglycans)
RN  - 75HGV0062C (glucuronyl glucosamine glycan sulfate)
RN  - 81604-65-1 (Heparin Cofactor II)
RN  - 9000-94-6 (Antithrombin III)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Animals
MH  - Antithrombin III/*pharmacology
MH  - Glycosaminoglycans/*pharmacology
MH  - Heparin/*pharmacology
MH  - Heparin Cofactor II/*pharmacology
MH  - Rabbits
MH  - Thrombin/*antagonists & inhibitors
MH  - Thrombosis/*prevention & control
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1016/0049-3848(94)90267-4 [doi]
PST - ppublish
SO  - Thromb Res. 1994 Jun 1;74(5):463-75. doi: 10.1016/0049-3848(94)90267-4.