PMID- 8088177
OWN - NLM
STAT- MEDLINE
DCOM- 19941018
LR  - 20041117
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 107
IP  - 3
DP  - 1994 Mar
TI  - Activation of bovine factor IX by the reaction product of bovine factor VII and 
      human tissue factor.
PG  - 181-5
AB  - A study was carried out on the alternate activation of factor IX (FIX) by bovine 
      FVII and human tissue factor (TF) rather than by activated factor XI (FXIa). The 
      reaction product of bovine FVII and human TF functioned as a FIX activator in the 
      assay system used. Published studies suggest that in the presence of Ca2+ ions, 
      the complex of human FVII-TF readily activates both human FIX and human FX, and 
      at low TF concentrations, FIX appears to be the preferred substrate for the 
      reaction product of FVII and TF. This may explain the discrepancy between the 
      mild bleeding of hereditary FXI deficiency and the severe bleeding of hereditary 
      FIX deficiency. The results obtained with bovine FVII and a crude human TF 
      preparation confirm that at low TF concentrations, bovine FIX is the preferred 
      substrate rather than FX. At higher TF concentrations, bovine FX was rapidly 
      activated.
FAU - Liu, D Y
AU  - Liu DY
AD  - National Institute for the Control of Pharmaceutical and Biological Products, 
      Beijing, P.R. China.
FAU - Rosen, S
AU  - Rosen S
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 9001-25-6 (Factor VII)
RN  - 9001-28-9 (Factor IX)
RN  - 9001-29-0 (Factor X)
RN  - 9035-58-9 (Thromboplastin)
RN  - EC 3.4.21.22 (Factor IXa)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Factor IX/*metabolism
MH  - Factor IXa/biosynthesis
MH  - Factor VII/*pharmacology
MH  - Factor X/metabolism
MH  - Factor Xa/biosynthesis
MH  - Humans
MH  - Thromboplastin/*pharmacology
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1994 Mar;107(3):181-5.