PMID- 8088771
OWN - NLM
STAT- MEDLINE
DCOM- 19941018
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 25
IP  - 9
DP  - 1994 Sep
TI  - Intrahepatic peribiliary vascular plexus in various hepatobiliary diseases: a 
      histological survey.
PG  - 940-6
AB  - The peribiliary vascular plexus (PVP) plays an important role in the 
      pathophysiology of the biliary tree. We histologically examined vascular 
      endothelial cells of the intrahepatic PVP in various hepatobiliary diseases by 
      immunohistochemistry and lectin histochemistry with antibodies to factor 
      VIII-related antigens (F-VIII-R-Ag) and Ulex europaeus agglutinin I (UEA-I). The 
      PVP around the intrahepatic large bile ducts (LBDs) and septal bile ducts (SBDs) 
      in normal livers consists of three layers: inner layer vessels immediately 
      adjacent to the epithelium, intermediate layer vessels within the ductal wall, 
      and outer layer vessels outside the ductal wall. In some bile ducts that show 
      active inflammation in hepatolithiasis, primary biliary cirrhosis (PBC), primary 
      sclerosing cholangitis (PSC), and extrahepatic biliary obstruction (EBO), vessels 
      in the intermediate layer and, to a lesser degree, in the inner layer, are 
      increased in number. In sclerotic bile ducts of PSC, EBO, and hepatolithiasis, 
      the number of inner and intermediate layer vessels are markedly and variably 
      reduced, respectively. In liver cirrhosis or chronic advanced liver diseases, the 
      vessels in all three layers, particularly those in the outer layer, are increased 
      in number and dilated, probably reflecting intrahepatic microcirculatory 
      disturbance. The PVP showed several types of numerical and luminal changes, each 
      of which may be related to disease processes in the intrahepatic biliary tree as 
      well as to intrahepatic microcirculatory disturbance.
FAU - Kobayashi, S
AU  - Kobayashi S
AD  - Department of Pathology (II), Kanazawa University School of Medicine, Japan.
FAU - Nakanuma, Y
AU  - Nakanuma Y
FAU - Matsui, O
AU  - Matsui O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
SB  - IM
MH  - Adult
MH  - Bile Duct Diseases/*pathology
MH  - Bile Ducts, Intrahepatic/*blood supply
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver/pathology
MH  - Liver Diseases/*pathology
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0046-8177(94)90016-7 [pii]
AID - 10.1016/0046-8177(94)90016-7 [doi]
PST - ppublish
SO  - Hum Pathol. 1994 Sep;25(9):940-6. doi: 10.1016/0046-8177(94)90016-7.