PMID- 8088830
OWN - NLM
STAT- MEDLINE
DCOM- 19941020
LR  - 20171116
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 21
IP  - 2
DP  - 1994 May 15
TI  - Direct evidence for homologous sequences on the paracentric regions of human 
      chromosome 1.
PG  - 359-63
AB  - Calcyclin is a member of the S100 family of proteins, many of which are encoded 
      by genes that have been localized to the proximal long arm of human chromosome 1 
      (bands q21-q22). A 450-kb yeast artificial chromosome clone containing the human 
      calcyclin gene was identified by PCR screening and used as a probe for 
      fluorescence in situ hybridization (FISH). Along with the expected hybridization 
      to 1q21, simultaneous, specific hybridization to the centromeric region of the 
      short arm of chromosome 1 was also observed. An identical pattern of 
      hybridization was observed when microdissected 1q21 DNA sequences were used as a 
      probe for FISH, confirming the presence of homologous sequences flanking both 
      sides of the centromere of human chromosome 1. These results are consistent with 
      a model in which human chromosome 1 arose by insertion of the centromere and 
      heterochromatin into an ancestral chromosome containing chromosome-specific 
      repetitive sequences.
FAU - Hardas, B D
AU  - Hardas BD
AD  - Department of Dermatology, University of Michigan, Ann Arbor 48109-0672.
FAU - Zhang, J
AU  - Zhang J
FAU - Trent, J M
AU  - Trent JM
FAU - Elder, J T
AU  - Elder JT
LA  - eng
GR  - R01 AR42248/AR/NIAMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (S100 Calcium Binding Protein A6)
RN  - 0 (S100 Proteins)
RN  - 0 (S100a6 protein, mouse)
RN  - 105504-00-5 (S100A6 protein, human)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Calcium-Binding Proteins/*genetics
MH  - *Cell Cycle Proteins
MH  - *Centromere
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 1
MH  - DNA Primers
MH  - Epidermal Growth Factor/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction/methods
MH  - S100 Calcium Binding Protein A6
MH  - *S100 Proteins
MH  - Sequence Homology, Nucleic Acid
EDAT- 1994/05/15 00:00
MHDA- 1994/05/15 00:01
CRDT- 1994/05/15 00:00
PHST- 1994/05/15 00:00 [pubmed]
PHST- 1994/05/15 00:01 [medline]
PHST- 1994/05/15 00:00 [entrez]
AID - S0888-7543(84)71277-8 [pii]
AID - 10.1006/geno.1994.1277 [doi]
PST - ppublish
SO  - Genomics. 1994 May 15;21(2):359-63. doi: 10.1006/geno.1994.1277.