PMID- 8091610
OWN - NLM
STAT- MEDLINE
DCOM- 19941020
LR  - 20191210
IS  - 0304-4017 (Print)
IS  - 0304-4017 (Linking)
VI  - 53
IP  - 1-2
DP  - 1994 May
TI  - Moxidectin: pharmacokinetics and activity against horn flies (Diptera: Muscidae) 
      and trichostrongyle nematode egg production.
PG  - 133-43
AB  - The concentration of moxidectin, a macrocyclic lactone endectocide, in the blood 
      serum of cattle resulting from single and daily subcutaneous injections and oral 
      dosing was determined as a function of time. When given as a single subcutaneous 
      (SC) injection, the drug peaked between 4 and 6 h post-treatment. As a single 
      oral dose, the peak serum level occurred at 1 day post-treatment. Daily SC 
      injections and oral doses resulted in a gradual increase in blood serum level 
      over the 21 days of treatment but did not reach a plateau during this time. Horn 
      flies, Haematobia irritans (Linnaeus), feeding on the blood of treated cattle 
      drawn on Day 21 of daily treatment showed a decline in survival and egg 
      production, but a negligible effect on egg hatching. Dose-mortality data on adult 
      horn flies showed an LC-50 and LC-90 value of 10 ppb and 19 ppb in the blood, 
      respectively. Moxidectin was also found to have larvicidal activity against the 
      immature stages of the horn fly in the manure of treated cattle. Moxidectin 
      administered at 100, 50 and 25 micrograms kg-1 as a daily oral medication was 
      100% effective in eliminating trichostrongyle egg counts by Day 3 of the 
      treatment. Counts remained negative to the end of the trial.
FAU - Miller, J A
AU  - Miller JA
AD  - U.S. Department of Agriculture, Knipling-Bushland U.S. Livestock Insects 
      Laboratory, Kerrville, TX 78028.
FAU - Oehler, D D
AU  - Oehler DD
FAU - Scholl, P J
AU  - Scholl PJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Anthelmintics)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Insecticides)
RN  - 0 (Macrolides)
RN  - 0 (Manure)
RN  - NGU5H31YO9 (moxidectin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Anthelmintics/*pharmacokinetics/pharmacology/therapeutic use
MH  - Anti-Bacterial Agents/*pharmacokinetics/pharmacology/therapeutic use
MH  - Cattle/*metabolism
MH  - Cattle Diseases/drug therapy/parasitology
MH  - Feces/parasitology
MH  - Female
MH  - Injections, Subcutaneous/veterinary
MH  - Insecticides/*pharmacokinetics
MH  - Macrolides
MH  - Male
MH  - Manure/parasitology
MH  - *Muscidae/physiology
MH  - Oviposition/drug effects
MH  - Parasite Egg Count/veterinary
MH  - Trichostrongyloidea/*drug effects/physiology
MH  - Trichostrongyloidiasis/drug therapy/parasitology/veterinary
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0304-4017(94)90025-6 [pii]
AID - 10.1016/0304-4017(94)90025-6 [doi]
PST - ppublish
SO  - Vet Parasitol. 1994 May;53(1-2):133-43. doi: 10.1016/0304-4017(94)90025-6.