PMID- 8093710
OWN - NLM
STAT- MEDLINE
DCOM- 19930219
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 100
IP  - 1
DP  - 1993 Jan
TI  - Pathomechanisms of photosensitive lupus erythematosus.
PG  - 58S-68S
AB  - This review discusses the mechanisms involved in different photosensitive lupus 
      syndromes: acute cutaneous lupus erythematosus, chronic cutaneous (discoid) lupus 
      erythematosus, subacute cutaneous lupus erythematosus, and neonatal lupus 
      erythematosus. It is proposed that there are three principal determinants of 
      photosensitivity in lupus: 1) susceptibility to UVR-induced release of epidermal 
      and dermal cytokines; 2) susceptibility to UVR-induced release or translocation 
      of sequestered antigens in the epidermis or dermis; and 3) different specific 
      immunologic effector mechanisms, activated by cytokines and directed against 
      discrete epidermal targets. Several characteristics of photosensitive lupus are 
      discussed in detail: autoantibody specificities, autoantigen translocation, 
      induction of epidermal intercellular adhesion molecule-a (ICAM-1), vascular 
      activation, cytokine release and T-cell activation, and clinical phototesting. 
      The role of antibodies to the extractable nuclear antigens Ro and La and the 
      relationship to subacute cutaneous lupus erythematosus (SCLE) and neonatal lupus 
      erythematosus is discussed in detail, and a model of SCLE is proposed.
FAU - Norris, D A
AU  - Norris DA
AD  - Department of Dermatology, University of Colorado School of Medicine, Denver 
      80262.
LA  - eng
GR  - AR26427/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Antibodies)
RN  - 0 (Antigens)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Antibody-Dependent Cell Cytotoxicity
MH  - Antigens/metabolism
MH  - Blood Vessels/radiation effects
MH  - Cell Adhesion Molecules/metabolism
MH  - Cytokines/physiology
MH  - Disease Models, Animal
MH  - Humans
MH  - Intercellular Adhesion Molecule-1
MH  - Keratinocytes/metabolism
MH  - Lupus Erythematosus, Cutaneous/*etiology/immunology
MH  - Lupus Erythematosus, Systemic/*etiology/immunology
MH  - Lymphocyte Activation
MH  - Photosensitivity Disorders/*etiology/immunology
MH  - Skin Tests
MH  - T-Lymphocytes/physiology
RF  - 96
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 0022-202X(93)92202-6 [pii]
AID - 10.1111/1523-1747.ep12355599 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1993 Jan;100(1):58S-68S. doi: 10.1111/1523-1747.ep12355599.