PMID- 8093836
OWN - NLM
STAT- MEDLINE
DCOM- 19930226
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 8
IP  - 1
DP  - 1993 Jan
TI  - Effects of cortical serotonin depletion induced by 
      3,4-methylenedioxymethamphetamine (MDMA) on behavior, before and after additional 
      cholinergic blockade.
PG  - 77-85
AB  - Repeated treatment with high doses of 3,4-methylenedioxymethamphetamine (MDMA; 
      "ecstasy") produces a long-lasting depletion of brain serotonin, presumably 
      because of the degeneration of serotonin axon terminals. However, very little is 
      known about the long-term behavioral consequences of MDMA neurotoxicity. The 
      experiments reported here were designed to evaluate the effects of MDMA 
      neurotoxicity on a number of behavioral tests known to be sensitive to 
      neocortical and hippocampal damage. Also, the effect of additional cholinergic 
      blockade in MDMA-pretreated rats was evaluated because loss of both the 
      serotonergic and cholinergic inputs to the cortex produces a functional 
      decortication and a behavioral syndrome reminiscent of human global dementia. 
      Partial depletion of neocortical serotonin (72.6%) did not produce deficits on a 
      variety of behavioral tests, including a place navigation learning-set task, 
      skilled forelimb use, or the ability to make complex judgements regarding the 
      stimulus properties of food in a foraging situation, and neither did additional 
      cholinergic blockade. MDMA-pretreated rats had a mild impairment in rapidly 
      developing an efficient search strategy in the place navigation task, but once 
      the goal was located, MDMA pretreated rats performed at control levels and showed 
      no deficits in memory for spatial location. It is concluded that the extent of 
      serotonergic denervation produced by MDMA is not sufficient to produce marked and 
      lasting behavioral deficits, possibly because of neurocompensatory changes in the 
      remaining serotonin terminals.
FAU - Robinson, T E
AU  - Robinson TE
AD  - Department of Psychology, University of Michigan, Ann Arbor 48109.
FAU - Castaneda, E
AU  - Castaneda E
FAU - Whishaw, I Q
AU  - Whishaw IQ
LA  - eng
GR  - 4294/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 7C0697DR9I (Atropine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Atropine/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Prosencephalon/*drug effects/physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*physiology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1038/npp.1993.9 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 1993 Jan;8(1):77-85. doi: 10.1038/npp.1993.9.