PMID- 8094113
OWN - NLM
STAT- MEDLINE
DCOM- 19930310
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 341
IP  - 8841
DP  - 1993 Feb 6
TI  - Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon 
      RI) on chromosome 11q.
PG  - 332-4
AB  - Atopy, a common familial syndrome underlying allergic asthma and rhinitis, is 
      characterised by sustained immunoglobulin E (IgE) responses to common allergens. 
      We have previously shown genetic linkage of atopy to the chromosome 11q13 marker 
      D11S97 (pms51) through maternally derived alleles, but no likely candidate genes 
      were known to lie near this marker. We have analysed maternally derived alleles 
      from 155 sibling-pairs affected by atopy to seek evidence of linkage between the 
      gene predisposing to atopy and other markers on chromosome 11q13. We found that 
      the beta subunit of the high-affinity receptor for IgE (Fc epsilon RI-beta) also 
      lies on chromosome 11q13, and that it is in close genetic linkage with the gene 
      for atopy. The known roles of Fc epsilon RI in antigen-induced mast-cell 
      degranulation and in the release of cytokines that enhance IgE production make 
      the gene for its beta subunit a candidate for the chromosome 11 atopy locus.
FAU - Sandford, A J
AU  - Sandford AJ
AD  - Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
FAU - Shirakawa, T
AU  - Shirakawa T
FAU - Moffatt, M F
AU  - Moffatt MF
FAU - Daniels, S E
AU  - Daniels SE
FAU - Ra, C
AU  - Ra C
FAU - Faux, J A
AU  - Faux JA
FAU - Young, R P
AU  - Young RP
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Lathrop, G M
AU  - Lathrop GM
FAU - Cookson, W O
AU  - Cookson WO
AU  - et al.
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Receptors, IgE)
SB  - IM
CIN - Lancet. 1993 May 22;341(8856):1346. PMID: 8098473
CIN - Lancet. 1993 Oct 9;342(8876):936. PMID: 8105198
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - Genetic Linkage
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics
MH  - Lod Score
MH  - Male
MH  - Receptors, IgE/*genetics
EDAT- 1993/02/06 00:00
MHDA- 1993/02/06 00:01
CRDT- 1993/02/06 00:00
PHST- 1993/02/06 00:00 [pubmed]
PHST- 1993/02/06 00:01 [medline]
PHST- 1993/02/06 00:00 [entrez]
AID - 0140-6736(93)90136-5 [pii]
AID - 10.1016/0140-6736(93)90136-5 [doi]
PST - ppublish
SO  - Lancet. 1993 Feb 6;341(8841):332-4. doi: 10.1016/0140-6736(93)90136-5.