PMID- 8094408
OWN - NLM
STAT- MEDLINE
DCOM- 19930315
LR  - 20171116
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 150
IP  - 4
DP  - 1993 Feb 15
TI  - Association of a V beta 2-specific superantigen with a tumorigenic milk-borne 
      mouse mammary tumor virus.
PG  - 1422-8
AB  - A number of endogenous mouse mammary tumor virus (MMTV) proviruses encode 
      superantigens that have the property of stimulating mature T lymphocytes in a TCR 
      V beta-specific fashion and of mediating V beta-specific clonal deletion in 
      developing T cells. The tumorigenic milk-borne MMTV carried by C3H and GR mice 
      also have superantigen properties in vivo, and it has been proposed that this 
      superantigenic function is critical to the infectivity and/or tumorigenicity of 
      the virus. To test the requirement for superantigen properties in tumorigenic 
      MMTV, a highly tumorigenic strain of MMTV isolated from BALB/c mice (BALB/cV 
      virus) was analyzed for its effect on TCR V beta expression. It was found that 
      exposure of newborn mice to milk-borne virus results in marked deletion of V beta 
      2-expressing CD4+ peripheral T cells. This deletion is detected in mature TCRhigh 
      thymocytes as well as in peripheral T cells from virus-exposed mice. Deletion is 
      dependent on expression of a permissive MHC type in mice exposed to virus. 
      Subcutaneous injection of adult mice with virus-containing milk induces a 
      substantial increase in V beta 2+ CD4+ cells in draining lymph nodes within 4 
      days. Thus, tumorigenic BALB/cV is associated with V beta 2-specific superantigen 
      activity capable of mediating both T cell expansion and clonal deletion in vivo. 
      These findings are consistent with a critical role of superantigen-mediated T 
      cell activation in MMTV infection and tumorigenesis.
FAU - Hodes, R J
AU  - Hodes RJ
AD  - Experimental Immunology Branch, National Cancer Institute, National Institutes of 
      Health, Bethesda, MD 20892.
FAU - Novick, M B
AU  - Novick MB
FAU - Palmer, L D
AU  - Palmer LD
FAU - Knepper, J E
AU  - Knepper JE
LA  - eng
GR  - CA-52853/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Viral)
RN  - 0 (CD8 Antigens)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8 Antigens/analysis
MH  - Female
MH  - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
MH  - Major Histocompatibility Complex
MH  - Mammary Neoplasms, Experimental/*immunology
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Receptors, Antigen, T-Cell, alpha-beta/*immunology
MH  - Thymus Gland/cytology/immunology
MH  - Time Factors
MH  - Tumor Virus Infections/immunology
EDAT- 1993/02/15 00:00
MHDA- 1993/02/15 00:01
CRDT- 1993/02/15 00:00
PHST- 1993/02/15 00:00 [pubmed]
PHST- 1993/02/15 00:01 [medline]
PHST- 1993/02/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1993 Feb 15;150(4):1422-8.