PMID- 8095030
OWN - NLM
STAT- MEDLINE
DCOM- 19930330
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 318
IP  - 3
DP  - 1993 Mar 8
TI  - A human synaptic vesicle monoamine transporter cDNA predicts posttranslational 
      modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs.
PG  - 325-30
AB  - A human vesicular monoamine transporter cDNA has been identified by screening a 
      human brainstem library using sequences from the rat brain synaptic vesicle 
      monoamine transporter (SVMT) [(1992) Cell 70, 539-551; (1992) Proc. Natl. Acad. 
      Sci. USA 89, 10993-10997]. The hSVMT shares 92% amino acid identity with the rat 
      sequence, but displays one less consensus site for asparagine N-linked 
      glycosylation and one more consensus site for phosphorylation by protein kinase 
      C. The human SVMT gene maps to chromosome 10q25 using Southern blotting analysis 
      of human/rodent hybrid cell lines and fluorescent in situ hybridization 
      approaches. The cDNA, and a subclone, recognize TaqI polymorphisms that may prove 
      useful to assess this gene's involvement in neuropsychiatric disorders involving 
      monoaminergic brain systems.
FAU - Surratt, C K
AU  - Surratt CK
AD  - Molecular Neurobiology, Addiction Research Center, NIDA, NIH, Baltimore, MD 
      21224.
FAU - Persico, A M
AU  - Persico AM
FAU - Yang, X D
AU  - Yang XD
FAU - Edgar, S R
AU  - Edgar SR
FAU - Bird, G S
AU  - Bird GS
FAU - Hawkins, A L
AU  - Hawkins AL
FAU - Griffin, C A
AU  - Griffin CA
FAU - Li, X
AU  - Li X
FAU - Jabs, E W
AU  - Jabs EW
FAU - Uhl, G R
AU  - Uhl GR
LA  - eng
SI  - GENBANK/L09118
GR  - 2P30 CA 06973-29/CA/NCI NIH HHS/United States
GR  - 5P01 GM1015-02/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (SLC18A2 protein, human)
RN  - 0 (Vesicular Biogenic Amine Transport Proteins)
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
RN  - EC 3.1.21.4 (TCGA-specific type II deoxyribonucleases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 10
MH  - Consensus Sequence
MH  - DNA/chemistry/*genetics
MH  - *Deoxyribonucleases, Type II Site-Specific
MH  - Glycoproteins/chemistry/*genetics
MH  - Glycosylation
MH  - Humans
MH  - In Situ Hybridization
MH  - *Membrane Glycoproteins
MH  - *Membrane Transport Proteins
MH  - Molecular Sequence Data
MH  - *Neuropeptides
MH  - Phosphorylation
MH  - *Polymorphism, Restriction Fragment Length
MH  - Protein Kinase C/metabolism
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Synaptic Vesicles/*chemistry
MH  - Vesicular Biogenic Amine Transport Proteins
MH  - Vesicular Monoamine Transport Proteins
EDAT- 1993/03/08 00:00
MHDA- 1993/03/08 00:01
CRDT- 1993/03/08 00:00
PHST- 1993/03/08 00:00 [pubmed]
PHST- 1993/03/08 00:01 [medline]
PHST- 1993/03/08 00:00 [entrez]
AID - 0014-5793(93)80539-7 [pii]
AID - 10.1016/0014-5793(93)80539-7 [doi]
PST - ppublish
SO  - FEBS Lett. 1993 Mar 8;318(3):325-30. doi: 10.1016/0014-5793(93)80539-7.