PMID- 8097547
OWN - NLM
STAT- MEDLINE
DCOM- 19930521
LR  - 20190825
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 18
IP  - 1-2
DP  - 1993 Apr
TI  - Barrel rotation evoked by intracerebroventricular injection of somatostatin and 
      arginine-vasopressin is accompanied by the induction of c-fos gene expression in 
      the granular cells of rat cerebellum.
PG  - 115-20
AB  - Intracerebroventricular (i.c.v.) injection of somatostatin (SS) or 
      arginine-vasopressin (AVP) elicits barrel rotation (BR) in rats. To identify the 
      potential neuron structures involved in this characteristic behavior, the 
      regional expression of the c-fos gene in rat brain after i.c.v. injection of SS 
      (10 micrograms) or AVP (1 micrograms) was examined by hybridization 
      histochemistry. The c-fos expression could serve as a marker of neuronal activity 
      and/or neural transmission. Following SS-induced BR, c-fos gene expression was 
      observed in the lingula, uvula, nodulus, simplex, centralis, and culmen of the 
      cerebellum, while following AVP-induced BR, c-fos gene expression was observed in 
      the first four of the above-mentioned regions of the cerebellum, but not in the 
      centralis or culmen. In these regions, the c-fos mRNA signals were observed on 
      the granular layer. Expression of the c-fos gene was immediately and transiently 
      induced and was not observed in rats in which BR was not evoked after SS or AVP 
      injection. In both control rats and SS- or AVP-injected rats, the c-fos gene 
      expression was induced in the piriform cortex and the flocculus of the 
      cerebellum. The findings suggest that BR is a manifestation of behavior induced 
      by massive transsynaptic activation of the granular cells in the cerebellum.
FAU - Kamegai, J
AU  - Kamegai J
AD  - Department of Medicine, Nippon Medical School, Tokyo, Japan.
FAU - Minami, S
AU  - Minami S
FAU - Sugihara, H
AU  - Sugihara H
FAU - Wakabayashi, I
AU  - Wakabayashi I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 51110-01-1 (Somatostatin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/administration & dosage/*pharmacology
MH  - Catalepsy/chemically induced
MH  - Cerebellar Cortex/cytology/*drug effects/physiology
MH  - Gene Expression Regulation/*drug effects
MH  - *Genes, fos
MH  - Injections, Intraventricular
MH  - Male
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Proto-Oncogene Proteins c-fos/*biosynthesis
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Rotation
MH  - Somatostatin/administration & dosage/*pharmacology
MH  - Stress, Physiological/chemically induced
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 0169-328X(93)90179-S [pii]
AID - 10.1016/0169-328x(93)90179-s [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1993 Apr;18(1-2):115-20. doi: 
      10.1016/0169-328x(93)90179-s.