PMID- 8097578
OWN - NLM
STAT- MEDLINE
DCOM- 19930521
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 57
IP  - 1
DP  - 1993 Jan
TI  - Effect of excitatory amino acid on the hypothalamo-pituitary-adrenal axis in the 
      rat during the stress-hyporesponsive period.
PG  - 70-8
AB  - During the postnatal period from day 2 to day 10 of life, basal and 
      stress-induced adrenocorticotropic hormone (ACTH) and corticosterone releases are 
      low as compared with adults. This period has been called the 
      'stress-hyporesponsive period', and its mechanisms are yet undetermined. In this 
      study, we have tested the effects of substances excitatory to neuronal activity 
      on the hypothalamic-pituitary-adrenal (HPA) axis. In 7-day-old rats, 
      administration of the excitatory amino acid (EAA) agonists N-methyl-D,L-aspartic 
      acid (NMA), quisqualic acid, and kainic acid (KA) induced a large increase in 
      plasma ACTH and corticosterone concentrations. All three EAA induced a rapid and 
      potent stimulation of ACTH release within 30 min, the effect on corticosterone 
      secretion being weaker. KA was the more potent EAA, followed by NMA and 
      quisqualic acid. The effect of NMA on the HPA axis was inhibited by pretreatment 
      with a competitive antagonist to N-methyl-D-aspartic acid receptors, 
      D,L-2-amino-5-phosphonovaleric acid. We next sought to determine which level of 
      the HPA axis was affected by EAA administration. Several EAA (glutamic acid, 
      N-methyl-D-aspartic acid, and KA from 10(-5) to 10(-2) M) had no stimulating 
      action on ACTH release from 7-day-old anterior pituitary glands incubated in 
      vitro. In vivo, the stimulating effect of NMA and KA on in vivo ACTH release was 
      blocked after passive immunization with an anti-corticotropin-releasing hormone 
      antiserum, but not after injection of an anti-arginine vasopressin 
      antiserum.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Chautard, T
AU  - Chautard T
AD  - Laboratories de Neuroendocrinologie Experimentale, INSERM U 297, Marseille, 
      France.
FAU - Boudouresque, F
AU  - Boudouresque F
FAU - Guillaume, V
AU  - Guillaume V
FAU - Oliver, C
AU  - Oliver C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Amino Acids)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - SIV03811UC (Kainic Acid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Adrenocorticotropic Hormone/*blood/metabolism
MH  - Amino Acids/*pharmacology
MH  - Animals
MH  - Corticosterone/*blood/metabolism
MH  - Corticotropin-Releasing Hormone/immunology
MH  - Hypothalamo-Hypophyseal System/*drug effects
MH  - In Vitro Techniques
MH  - Kainic Acid/pharmacology
MH  - N-Methylaspartate/pharmacology
MH  - Pituitary-Adrenal System/*drug effects/metabolism
MH  - Quisqualic Acid/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Physiological/*blood
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1159/000126344 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1993 Jan;57(1):70-8. doi: 10.1159/000126344.