PMID- 8097718
OWN - NLM
STAT- MEDLINE
DCOM- 19930528
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 228
IP  - 5-6
DP  - 1993 Apr 1
TI  - Drug effects on distribution of [3H]3,4-methylenedioxymethamphetamine in mice.
PG  - 247-56
AB  - The present study was undertaken to examine the drug interactions between 
      3,4-methylenedioxymethamphetamine (MDMA) and paroxetine or several compounds 
      including the 3,4-methylenedioxybenzyl (piperonyl) group in mice. The time course 
      of radioactivity in the mouse brain after i.v. administration of the tracer 
      amount (approximately 70 ng/kg) of [3H]MDMA was altered significantly by 
      coinjection of carrier MDMA (15 mg/kg) or by pretreatment with paroxetine (10 
      mg/kg, i.p., 5 min). Furthermore, the radioactivity in the brain 60 min after 
      injection of [3H]MDMA was increased significantly by pretreatment with 
      paroxetine, but not by pretreatment with 6-nitroquipazine, fluoxetine, 
      clomipramine, GBR 12909 or desipramine, indicating that paroxetine-induced 
      alteration of the brain radioactivity was not due to the inhibitory effect of 
      5-hydroxytryptamine (5-HT) uptake of paroxetine. The radioactivity in the brain 
      60 min after injection of [3H]MDMA was increased significantly by pretreatment 
      with 3,4-methylenedioxyamphetamine (MDA), MDMA, 1-piperonylpiperazine and N, 
      alpha-dimethylpiperonylamine, but not by pretreatment with piperonylacetone, 
      piperonyl butoxide and piperonyl isobutyrate. HPLC analyses indicated that the 
      alteration of brain radioactivity 60 min after injection of [3H]MDMA was, in 
      part, due to inhibition in the metabolism of [3H]MDMA to radioactive 
      metabolite(s). The present results suggest that a specific mechanism for the 
      3,4-methylenedioxyphenyl group which rapidly alters the disposition and 
      metabolism of [3H]MDMA may exist in brain and peripheral organs of mice.
FAU - Hashimoto, K
AU  - Hashimoto K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, 
      Japan.
FAU - Maeda, H
AU  - Maeda H
FAU - Hirai, K
AU  - Hirai K
FAU - Goromaru, T
AU  - Goromaru T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 41VRH5220H (Paroxetine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacokinetics
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Drug Interactions
MH  - Injections, Intravenous
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Paroxetine/pharmacology
MH  - Tissue Distribution/drug effects
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1016/0926-6917(93)90057-w [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1993 Apr 1;228(5-6):247-56. doi: 10.1016/0926-6917(93)90057-w.