PMID- 8098714
OWN - NLM
STAT- MEDLINE
DCOM- 19930623
LR  - 20220408
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 76
IP  - 5
DP  - 1993 May
TI  - Increased basic fibroblast growth factor in plasma from multiple endocrine 
      neoplasia type 1: relation to pituitary tumor.
PG  - 1182-7
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder 
      characterized by tumors of the parathyroids, pancreatic islets, and anterior 
      pituitary. We previously reported a basic fibroblast growth factor (bFGF)-like 
      substance in the plasma of subjects with MEN1. In the present study we used a 
      novel sensitive specific 2-site immunoradiometric assay to test for bFGF in 
      plasma. The assay employs immobilized affinity-purified N-terminal-specific 
      anti-bFGF antibodies (antigen capture) and high affinity binding to 
      radioiodinated heparin. bFGF-like immunoreactivity was undetectable (< 0.2 ng/mL) 
      in normal subjects and in most unaffected relatives of MEN1 subjects. We found 
      detectable bFGF ranging from 0.24-1.28 ng/mL in 21 of 50 subjects with MEN1. 
      Seven of 8 MEN1 subjects with untreated pituitary tumors had detectable plasma 
      bFGF-like immunoreactivity. Plasma bFGF-like immunoreactivity decreased after 
      surgery for pituitary tumor in 4 patients and after initiation of bromocryptine 
      therapy in 4 patients. bFGF was increased in the plasma of several subjects with 
      sporadic endocrine disorders, including 3 with untreated or persistent 
      acromegaly. We conclude that pituitary tumor is a possible source of high 
      circulating bFGF immunoreactivity in MEN1 plasma.
FAU - Zimering, M B
AU  - Zimering MB
AD  - Metabolic Diseases Branch, National Institutes of Diabetes and Digestive and 
      Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
FAU - Katsumata, N
AU  - Katsumata N
FAU - Sato, Y
AU  - Sato Y
FAU - Brandi, M L
AU  - Brandi ML
FAU - Aurbach, G D
AU  - Aurbach GD
FAU - Marx, S J
AU  - Marx SJ
FAU - Friesen, H G
AU  - Friesen HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endocrine Gland Neoplasms/blood
MH  - Endocrine System Diseases/blood
MH  - Female
MH  - Fibroblast Growth Factor 2/*blood
MH  - Humans
MH  - Immunoradiometric Assay
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*blood
MH  - Pituitary Neoplasms/*blood/therapy
EDAT- 1993/05/01 00:00
MHDA- 1993/05/01 00:01
CRDT- 1993/05/01 00:00
PHST- 1993/05/01 00:00 [pubmed]
PHST- 1993/05/01 00:01 [medline]
PHST- 1993/05/01 00:00 [entrez]
AID - 10.1210/jcem.76.5.8098714 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1993 May;76(5):1182-7. doi: 10.1210/jcem.76.5.8098714.