PMID- 8099273
OWN - NLM
STAT- MEDLINE
DCOM- 19930701
LR  - 20190704
IS  - 0004-0010 (Print)
IS  - 0004-0010 (Linking)
VI  - 128
IP  - 6
DP  - 1993 Jun
TI  - Cause of death in multiple endocrine neoplasia type 1.
PG  - 683-90
AB  - OBJECTIVE: Little data are available on the natural history of untreated multiple 
      endocrine neoplasia type 1 (MEN-1). These data are essential in deciding 
      treatment that may carry significant morbidity. We determined the causes of death 
      in a large MEN-1 kindred with data available over a period of 130 years. Most 
      cases were unrecognized as MEN-1 at the time of patient's death. DESIGN: 
      Retrospective study of recorded medical data from 1861 to 1991. PATIENTS: One 
      hundred fifty-nine deaths occurred, of which 46 were in individuals classified as 
      "highly probable" of having MEN-1. RESULTS: Of 46 deaths in those classified as 
      "highly probable" of having MEN-1, 20 (43.5%) died of a recognized complication 
      of MEN-1 (12 of malignant neoplasms, six of renal calculi, and two of peptic 
      ulcer). If accidental deaths are excluded, 50% of the deaths in patients with 
      MEN-1 were the result of MEN-1, and the mean age of death (50.9 years)was 
      significantly younger than that of other family members. CONCLUSIONS: It is 
      concluded that MEN-1 leads to premature death, and that neoplasia rather than 
      peptic ulcer disease is the main cause of death. Deaths from pituitary tumor or 
      malignant endocrine tumors within the thorax were just as common or more common 
      than deaths from pancreatic malignant neoplasms.
FAU - Wilkinson, S
AU  - Wilkinson S
AD  - Department of Surgery, University of Tasmania, Hobart, Australia.
FAU - Teh, B T
AU  - Teh BT
FAU - Davey, K R
AU  - Davey KR
FAU - McArdle, J P
AU  - McArdle JP
FAU - Young, M
AU  - Young M
FAU - Shepherd, J J
AU  - Shepherd JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Surg
JT  - Archives of surgery (Chicago, Ill. : 1960)
JID - 9716528
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cause of Death
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/genetics/*mortality
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tasmania/epidemiology
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 10.1001/archsurg.1993.01420180085016 [doi]
PST - ppublish
SO  - Arch Surg. 1993 Jun;128(6):683-90. doi: 10.1001/archsurg.1993.01420180085016.