PMID- 8099337
OWN - NLM
STAT- MEDLINE
DCOM- 19930707
LR  - 20190830
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 59
IP  - 1
DP  - 1993 Apr
TI  - EMIT-d.a.u. monoclonal amphetamine/methamphetamine assay. II. Detection of 
      methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA).
PG  - 63-70
AB  - The cross-reactivity, stereoselectivity and clinical performance of the 
      EMIT-d.a.u. monoclonal amphetamine/methamphetamine immunoassay (EM) for the 
      detection of methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine 
      (MDMA) in urine was evaluated. The cut-off concentrations of racemic MDA and MDMA 
      were found to be approximately 800 ng/ml and 3000 ng/ml, respectively. The EM 
      assay demonstrated a high selectivity for the S(+) isomer of both MDA and MDMA. 
      Urines collected over a 24-h period from rats administered 20 mg i.v. racemic 
      MDMA were all positive when analyzed by the EM assay. The EM was found vastly 
      superior to the EMIT d.a.u. polyclonal amphetamine/methamphetamine assay for the 
      detection of MDA and MDMA. The EM assay displayed sufficient sensitivity for 
      detection of these drugs following clinical intoxication.
FAU - Poklis, A
AU  - Poklis A
AD  - Department of Pathology, Medical College of Virginia Hospitals, Virginia 
      Commonwealth University, Richmond 23298-0597.
FAU - Fitzgerald, R L
AU  - Fitzgerald RL
FAU - Hall, K V
AU  - Hall KV
FAU - Saady, J J
AU  - Saady JJ
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Designer Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/analogs & 
      derivatives/chemistry/*urine
MH  - Amphetamine/chemistry/*urine
MH  - Animals
MH  - Cross Reactions
MH  - Designer Drugs/administration & dosage
MH  - Gas Chromatography-Mass Spectrometry
MH  - *Immunoassay
MH  - Injections, Intravenous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Sensitivity and Specificity
MH  - Stereoisomerism
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 0379-0738(93)90312-X [pii]
AID - 10.1016/0379-0738(93)90312-x [doi]
PST - ppublish
SO  - Forensic Sci Int. 1993 Apr;59(1):63-70. doi: 10.1016/0379-0738(93)90312-x.