PMID- 8099530
OWN - NLM
STAT- MEDLINE
DCOM- 19930709
LR  - 20221207
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 71
IP  - 12
DP  - 1993 Jun 15
TI  - Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a 
      low-prevalence Alaska Native population. Implications for disease surveillance.
PG  - 4072-6
AB  - An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human 
      T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat 
      Eskimo man with no behavioral risk factors for HTLV-I infection. The case was 
      characterized by lack of atypical circulating lymphocytes, hypercalcemia, and 
      opportunistic infections; and by complete remission of the initial renal 
      parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) 
      immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, 
      were identified in specimens collected 31 months before the onset of illness, at 
      the time of diagnosis, and up to 37 months later, shortly before the patient's 
      death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral 
      blood mononuclear cells and in lymphoma in involved skin. Clinicians should be 
      alert to sporadic cases of both atypical and classic ATL, even in populations in 
      which the prevalence of HTLV-I infection is low.
FAU - Davidson, M
AU  - Davidson M
AD  - Arctic Investigations Program, National Center for Infectious Diseases, Centers 
      for Disease Control and Prevention, Anchorage, AK 99501.
FAU - Braziel, R M
AU  - Braziel RM
FAU - Lairmore, M D
AU  - Lairmore MD
FAU - Jacobson, S
AU  - Jacobson S
FAU - Sprott, J M
AU  - Sprott JM
FAU - Tucker, S B
AU  - Tucker SB
FAU - Levine, P H
AU  - Levine PH
FAU - Kaplan, J E
AU  - Kaplan JE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Alaska
MH  - CD4-Positive T-Lymphocytes/pathology
MH  - DNA, Viral/analysis
MH  - Human T-lymphotropic virus 1/genetics
MH  - Humans
MH  - *Inuit
MH  - Kidney Neoplasms/microbiology/*pathology
MH  - Leukemia-Lymphoma, Adult T-Cell/microbiology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Prevalence
MH  - Skull Neoplasms/pathology
MH  - T-Lymphocytes, Helper-Inducer/pathology
EDAT- 1993/06/15 00:00
MHDA- 1993/06/15 00:01
CRDT- 1993/06/15 00:00
PHST- 1993/06/15 00:00 [pubmed]
PHST- 1993/06/15 00:01 [medline]
PHST- 1993/06/15 00:00 [entrez]
AID - 10.1002/1097-0142(19930615)71:12<4072::aid-cncr2820711244>3.0.co;2-o [doi]
PST - ppublish
SO  - Cancer. 1993 Jun 15;71(12):4072-6. doi: 
      10.1002/1097-0142(19930615)71:12<4072::aid-cncr2820711244>3.0.co;2-o.