PMID- 8099720
OWN - NLM
STAT- MEDLINE
DCOM- 19930712
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 57
IP  - 2
DP  - 1993
TI  - Evidence for a common neural mechanism mediating growth hormone-releasing 
      factor-induced and somatostatin-induced feeding.
PG  - 299-305
AB  - We have previously reported that the somatotropin regulatory peptides, growth 
      hormone-releasing hormone (GRF) and somatostatin (SS) increase feeding when 
      applied centrally in low picomole-range doses. The similarity between the 
      dose-response characteristics and photoperiod sensitivities of these two 
      peptide's feeding effects, together with indirect evidence suggesting that these 
      peptides interact functionally within the hypothalamus, suggests that GRF and SS 
      may induce feeding via a common neural mechanism. The present studies sought to 
      investigate this possibility. In the first experiment combined 
      intracerebroventricular (icv) injections of optimal doses of GRF and SS were 
      found to be less potent than icv injections of GRF or SS alone, suggesting that 
      the mechanisms mediating GRF-induced and SS-induced feeding are not totally 
      independent. In further studies, icv injections of antiserum raised against SS 
      blocked GRF-induced feeding. In contrast, icv injections of antiserum raised 
      against GRF were ineffective in blocking SS-induced feeding. These results 
      suggest that SS may act downstream to GRF in a putative neural feeding mechanism 
      which utilizes both peptides. The possible anatomical basis for such a feeding 
      mechanism involving GRF and SS is discussed.
FAU - Feifel, D
AU  - Feifel D
AD  - Department of Psychiatry, University of California, San Diego, La Jolla.
FAU - Vaccarino, F J
AU  - Vaccarino FJ
FAU - Rivier, J
AU  - Rivier J
FAU - Vale, W W
AU  - Vale WW
LA  - eng
GR  - DK26741/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 51110-01-1 (Somatostatin)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Eating/*drug effects
MH  - Growth Hormone-Releasing Hormone/administration & dosage/immunology/*pharmacology
MH  - Immunization, Passive
MH  - Male
MH  - Photoperiod
MH  - Rats
MH  - Rats, Wistar
MH  - Somatostatin/administration & dosage/*pharmacology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1159/000126372 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1993;57(2):299-305. doi: 10.1159/000126372.