PMID- 8100759
OWN - NLM
STAT- MEDLINE
DCOM- 19930812
LR  - 20190721
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 38
IP  - 7
DP  - 1993 Jul
TI  - Gastric endocrine cell evolution in patients with Zollinger-Ellison syndrome. 
      Influence of gastrinoma growth and long-term omeprazole treatment.
PG  - 1307-17
AB  - Evolution of gastrinoma tumoral mass, fasting serum gastrin concentrations, and 
      gastric endocrine cells has been analyzed in 21 patients with the 
      Zollinger-Ellison syndrome committed to long-term omeprazole treatment (up to 
      7.75 years, median 37 months). Gastrinoma growth was seen in eight patients. 
      Significant increase in serum gastrin was only observed in the group of patients 
      with gastrinoma growth. Fundic argyrophil cell densities were correlated with 
      serum gastrin (r' = 0.68, P = 0.002). Argyrophil and antral gastrin cell 
      densities significantly increased during the survey, but increases were greater 
      in the group with gastrinoma growth (respectively, +136% and +131%) than in the 
      other group (respectively, +34% and +43%). Progression in the degree of 
      argyrophil cell hyperplasia, noted qualitatively, was observed in 11 patients. 
      Fundic carcinoids developed in three of these 11 patients, all three having 
      multiple endocrine neoplasia type 1 (MEN 1). Positive linear individual 
      correlations (r > or = 0.85) between argyrophil cell densities and corresponding 
      durations of omeprazole treatment were found in nine of the 10 patients studied 
      at least three times and who had a clear-cut increase in those cell densities. 
      Thus, increase in serum gastrin and fundic argyrophil cell densities appeared 
      closely associated with gastrinoma growth; however, duration of drug-induced 
      hypochlorhydria may also affect cell proliferation.
FAU - Cadiot, G
AU  - Cadiot G
AD  - Department of Gastroenterology, Hopital Bichat-Claude Bernard, Paris, France.
FAU - Lehy, T
AU  - Lehy T
FAU - Ruszniewski, P
AU  - Ruszniewski P
FAU - Bonfils, S
AU  - Bonfils S
FAU - Mignon, M
AU  - Mignon M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Gastrins)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - APUD Cells/*drug effects/pathology
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Chronic Disease
MH  - Female
MH  - Gastrinoma/blood/*drug therapy/epidemiology/pathology
MH  - Gastrins/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/blood/drug therapy/epidemiology/pathology
MH  - Omeprazole/*therapeutic use
MH  - Pancreatic Neoplasms/blood/*drug therapy/epidemiology/pathology
MH  - Prospective Studies
MH  - Stomach/*drug effects/pathology
MH  - Time Factors
MH  - Zollinger-Ellison Syndrome/blood/*drug therapy/epidemiology/pathology
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.1007/BF01296083 [doi]
PST - ppublish
SO  - Dig Dis Sci. 1993 Jul;38(7):1307-17. doi: 10.1007/BF01296083.