PMID- 8101435
OWN - NLM
STAT- MEDLINE
DCOM- 19930819
LR  - 20190914
IS  - 0003-4800 (Print)
IS  - 0003-4800 (Linking)
VI  - 57
IP  - 1
DP  - 1993 Jan
TI  - Linkage analysis of 7 polymorphic markers at chromosome 11p11.2-11q13 in 27 
      multiple endocrine neoplasia type 1 families.
PG  - 17-25
AB  - The multiple endocrine neoplasia type 1 (MEN1) locus has been previously 
      localized to 11q13 by combined tumour deletion mapping and linkage studies. 
      Family linkage analysis has defined the locus order as 11 cen-PGA-(PYGM, 
      MEN1)-(D11S97, D11S146)-INT2-11qter, and tumour deletion mapping studies have 
      suggested that the MEN1 locus is proximal to D11S146 but distal to PYGM. In order 
      to establish further the location of MEN1, we have utilized the seven polymorphic 
      DNA probes: D11S288, D11S149, PGA, PYGM, D11S97, D11S146 and INT2, in linkage 
      studies of 339 members (116 affected) from 27 MEN1 families. Linkage between MEN1 
      and 6 of the 7 loci was established, and the highest peak lod scores [Z(theta)] 
      were observed with PYGM and D11S97 at Z(theta) = 13.71, theta = 0.047 and 
      Z(theta) = 13.76, theta = 0.076 respectively. Multilocus analysis suggested the 
      most likely locus order as: 11 pter-(D11S288, D11S149)-11 
      cen-PGA-PYGM-MEN1-D11S97-D11S146-INT2-1 1qter. In addition, an examination of 
      individual recombinants indicated a centromeric location of D11S149 in relation 
      to D11S288. Thus, the results of our study, which favoured a location of MEN1 
      proximal to D11S97 and distal to PYGM, have established a panel of recombinants 
      that will facilitate further meiotic mapping studies of the MEN1 locus.
FAU - Thakker, R V
AU  - Thakker RV
AD  - Division of Molecular Medicine, MRC Clinical Research Centre, Harrow, UK.
FAU - Wooding, C
AU  - Wooding C
FAU - Pang, J T
AU  - Pang JT
FAU - Farren, B
AU  - Farren B
FAU - Harding, B
AU  - Harding B
FAU - Anderson, D C
AU  - Anderson DC
FAU - Besser, G M
AU  - Besser GM
FAU - Bouloux, P
AU  - Bouloux P
FAU - Brenton, D P
AU  - Brenton DP
FAU - Buchanan, K D
AU  - Buchanan KD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 0 (Genetic Markers)
SB  - IM
GS  - INT2
GS  - MEN1
GS  - PGA
GS  - PYGM
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - *Genetic Linkage
MH  - Genetic Markers
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - Recombination, Genetic
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1111/j.1469-1809.1993.tb00883.x [doi]
PST - ppublish
SO  - Ann Hum Genet. 1993 Jan;57(1):17-25. doi: 10.1111/j.1469-1809.1993.tb00883.x.