PMID- 8102033
OWN - NLM
STAT- MEDLINE
DCOM- 19930902
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 143
IP  - 2
DP  - 1993 Aug
TI  - Proliferation of endothelial component of parathyroid gland in multiple endocrine 
      neoplasia type 1. Potential relationship with a mitogenic factor.
PG  - 612-7
AB  - The basic fibroblast growth factor-like mitogen detected in the plasma of 
      patients with the multiple endocrine neoplasia type 1 (MEN-1) syndrome was found 
      to have a specific mitogenic effect on parathyroid endothelial cells in vitro. To 
      investigate its pathogenic role in humans, the endothelial component of 
      parathyroid glands was evaluated by ultrastructural morphometry in six MEN-1 
      patients. The results were compared with those found in six patients with uremic 
      hyperparathyroidism (UHPT) and in three subjects with histologically normal 
      glands. Plasma mitogenic activity was found in all MEN-1 patients but not in 
      those with UHPT or in normal subjects. All morphometric parameters investigated 
      (fractional volume and nuclear density of capillary endothelial cells, volume 
      fraction and number per unit area of capillaries) showed 1.5- to 2-fold higher 
      values in patients with MEN-1 than in those with UHPT (P < 0.05). In contrast, no 
      difference was found between MEN-1 cases and normal subjects. Quantitative 
      evaluation of parathyroid pericytes yielded results similar to those of 
      endothelial cells. These data indicate that the proliferation of parathyroid 
      cells in MEN-1 patients is accompanied by parallel increase in the associated 
      endothelial component that does not occur in patients with UHPT and may support 
      the hypothesis of an in vivo role of the MEN-1 mitogen factor on the endothelial 
      component of parathyroid glands in MEN-1 patients.
FAU - D'Adda, T
AU  - D'Adda T
AD  - Institutes of Pathological Anatomy, University of Parma, Italy.
FAU - Amorosi, A
AU  - Amorosi A
FAU - Bussolati, G
AU  - Bussolati G
FAU - Brandi, M L
AU  - Brandi ML
FAU - Bordi, C
AU  - Bordi C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Blood Proteins)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Blood Proteins/pharmacology
MH  - Cattle
MH  - Cell Division
MH  - Cells, Cultured/drug effects
MH  - Endothelium, Vascular/*ultrastructure
MH  - Female
MH  - Fibroblast Growth Factor 2/*pharmacology
MH  - Humans
MH  - Hyperparathyroidism, Secondary/blood
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/blood/immunology/*ultrastructure
MH  - Parathyroid Glands/*ultrastructure
MH  - Uremia/blood
PMC - PMC1887034
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
PMCR- 1994/02/01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
PHST- 1994/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1993 Aug;143(2):612-7.