PMID- 8102655
OWN - NLM
STAT- MEDLINE
DCOM- 19930917
LR  - 20190817
IS  - 0021-5287 (Print)
IS  - 0021-5287 (Linking)
VI  - 84
IP  - 7
DP  - 1993 Jul
TI  - [Study on gamma-GTP activity in urine and renal tissue of drug-induced 
      nephrotoxicity in rats].
PG  - 1197-205
AB  - We investigated changes of urinary and renal gamma-glutamyl transpeptidase 
      (gamma-GPT) activities in rat with renal damages caused by nephrotoxic agents in 
      order to clarify the onset and the course of these nephrotoxicities. Cisplatin 
      (CDDP) which is an antitumor agent, cephaloridine (CER) which is the 
      first-generation cephem, and gentamicin (GM) which is an aminoglycoside were 
      employed as tested nephrotoxic agents. We administered three fourth of LD50 of 
      each agent to male Fischer 344 rats, intra-peritoneally. And the time-course 
      changes of serum creatinine (s-Cr) value, creatinine clearance (Ccr) and urinary 
      gamma-GTP activity were observed after administration of each agent. Finally, we 
      measured renal gamma-GTP activities and observed pathological changes of the 
      kidneys. The elevation of s-cr values and the reduction of Ccr appeared 3 days 
      and 12 hours after the administration of CDDP and CER, respectively. And the peak 
      appeared 7 days and 3 days after the administration of CDDP and CER, 
      respectively. Increase of urinary gamma-GTP activities occurred earlier than the 
      peak of s-cr value and Ccr in each group and as early 12 hours after the 
      administration. In CER groups, the peak of urinary gamma-GTP activities was 
      observed within 12 hours after the administration. And the peak of urinary 
      gamma-GTP activities was observed at 24 hours and in 3 days after the 
      administration of GM and CDDP, respectively. In addition, renal gamma-GTP 
      activities reduced around 40% of those of control.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Furuta, N
AU  - Furuta N
AD  - Department of Urology, Jikei University, School of Medicine.
FAU - Nakada, J
AU  - Nakada J
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Nihon Hinyokika Gakkai Zasshi
JT  - Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
JID - 2984841R
RN  - 0 (Gentamicins)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - LVZ1VC61HB (Cephaloridine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Cephaloridine/*adverse effects
MH  - Cisplatin/*adverse effects
MH  - Gentamicins/*adverse effects
MH  - Kidney/*drug effects/enzymology
MH  - Kidney Diseases/chemically induced/*enzymology/*pathology
MH  - Kidney Tubules, Proximal/pathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - gamma-Glutamyltransferase/*metabolism/urine
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 10.5980/jpnjurol1989.84.1197 [doi]
PST - ppublish
SO  - Nihon Hinyokika Gakkai Zasshi. 1993 Jul;84(7):1197-205. doi: 
      10.5980/jpnjurol1989.84.1197.