PMID- 8103533
OWN - NLM
STAT- MEDLINE
DCOM- 19931001
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 43
IP  - 3
DP  - 1993 Jun
TI  - Effects of cocaine on baroreflex control of heart rate in conscious rats.
PG  - 257-66
AB  - Cocaine administration elicits a pressor response reportedly dependent upon 
      central and peripheral actions. The present study was designed specifically to 
      determine whether cocaine affects baroreflex sensitivity and whether this is 
      mediated by an action in the CNS. Baroreflex control of heart rate was assessed 
      by noting the change in the duration of the arterial pulse pressure or in the 
      heart rate elicited by administration of pressor and depressor agents. The 
      effects of intracerebroventricular and intravenous cocaine administration were 
      compared. Cocaine (0.1-0.15 mg/kg/min, i.v.) produced a decrease in baroreflex 
      sensitivity that was greater than that produced by an approximately equipressor 
      infusion of phenylephrine (0.5-1.3 micrograms/kg/min, i.v.). 
      Intracerebroventricular (i.c.v.) administration of cocaine (1.5-150 micrograms) 
      or procaine (100 micrograms) had no effect on arterial pressure, heart rate or 
      baroreflex control of heart rate. Furthermore, central administration of 
      yohimbine (3 and 10 micrograms, i.c.v.) was capable of preventing the suppression 
      of the heart rate responses induced by cocaine administration. Propranolol (15 
      micrograms, i.c.v.) was not able to attenuate the suppression of baroreflex 
      sensitivity elicited by intravenous cocaine administration but higher doses 
      (50-150 micrograms, i.c.v.) could mimic this effect. These data suggest that 
      cocaine suppresses baroreflex control of heart rate by a central alpha 
      2-adrenergic mechanism. In contrast, the pressor response to intravenous cocaine 
      is not likely to be dependent upon a forebrain periventricular site.
FAU - Knuepfer, M M
AU  - Knuepfer MM
AD  - Department of Pharmacological and Physiological Science, St. Louis University 
      School of Medicine, MO 63104.
FAU - McCann, R K
AU  - McCann RK
FAU - Kamalu, L
AU  - Kamalu L
LA  - eng
GR  - DA 05180/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 4Z8Y51M438 (Procaine)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Adrenergic beta-Antagonists/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cocaine/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Heart Rate/*drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Pressoreceptors/*drug effects
MH  - Procaine/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adrenergic, alpha/drug effects
MH  - Receptors, Adrenergic, beta/drug effects
MH  - Reflex/*drug effects
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
AID - 0165-1838(93)90332-O [pii]
AID - 10.1016/0165-1838(93)90332-o [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1993 Jun;43(3):257-66. doi: 10.1016/0165-1838(93)90332-o.