PMID- 8103542
OWN - NLM
STAT- MEDLINE
DCOM- 19931006
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 64
IP  - 2
DP  - 1993 Aug
TI  - A comparison of the yields of translocations and dicentrics measured using 
      fluorescence in situ hybridization.
PG  - 185-7
AB  - Chromosome aberration analysis using fluorescence in situ hybridization (FISH) 
      methods without centromere-specific markers results in the misscoring of a 
      substantial fraction of the dicentrics as translocations; that is, too many 
      translocations and too few dicentrics are scored. Such misscoring has led to 
      considerable confusion in the rapidly emerging literature on FISH-based 
      cytogenetics. Here, we demonstrate that the problem is fully resolved when 
      centromeric probes are used.
FAU - Straume, T
AU  - Straume T
AD  - University of California, Lawrence Livermore National Laboratory, Livermore, CA 
      94551.
FAU - Lucas, J N
AU  - Lucas JN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (DNA Probes)
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human/*radiation effects
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Translocation, Genetic
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 66BHHGKE3914CMKQ [pii]
AID - 10.1080/09553009314551281 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1993 Aug;64(2):185-7. doi: 10.1080/09553009314551281.