PMID- 8103929
OWN - NLM
STAT- MEDLINE
DCOM- 19931012
LR  - 20211203
IS  - 0962-8436 (Print)
IS  - 0962-8436 (Linking)
VI  - 340
IP  - 1293
DP  - 1993 Jun 29
TI  - Genetic dissection of signal transduction mediated by the sevenless receptor 
      tyrosine kinase in Drosophila.
PG  - 273-8
AB  - The specification of the R7 photoreceptor cell fate in the developing eye of 
      Drosophila depends on the local activation of the sevenless (Sev) receptor 
      tyrosine kinase by Boss, a protein expressed on the membrane of the neighbouring 
      R8 cell. Constitutive activation of the Sev receptor results in a 
      dosage-dependent increase in the number of R7 cells per ommatidium. Genetic 
      screens have been used to identify mutations that alter the efficiency of signal 
      transduction. Subsequent molecular characterization of the corresponding genes 
      has led to the identification of a number of proteins involved in transducing the 
      signal from the receptor to the nucleus. In contrast to the receptor and its 
      ligand, these components are shared between different signal transduction 
      pathways not only in Drosophila but are also homologous to components involved in 
      signal transduction in other organisms.
FAU - Hafen, E
AU  - Hafen E
AD  - Zoologisches Institut, Universitat Zurich, Switzerland.
FAU - Dickson, B
AU  - Dickson B
FAU - Brunner, T
AU  - Brunner T
FAU - Raabe, T
AU  - Raabe T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
RN  - 0 (Drosophila Proteins)
RN  - 0 (Eye Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (sev protein, Drosophila)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-raf)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/physiology
MH  - Drosophila/enzymology/*physiology
MH  - *Drosophila Proteins
MH  - Eye Proteins/*metabolism
MH  - Genes, Recessive
MH  - Membrane Glycoproteins/*metabolism
MH  - Mutation
MH  - Photoreceptor Cells/physiology
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-raf
MH  - *Receptor Protein-Tyrosine Kinases
MH  - Receptors, Cell Surface/*metabolism
MH  - *Signal Transduction
MH  - Species Specificity
MH  - Vertebrates/physiology
RF  - 52
EDAT- 1993/06/29 00:00
MHDA- 1993/06/29 00:01
CRDT- 1993/06/29 00:00
PHST- 1993/06/29 00:00 [pubmed]
PHST- 1993/06/29 00:01 [medline]
PHST- 1993/06/29 00:00 [entrez]
AID - 10.1098/rstb.1993.0068 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340(1293):273-8. doi: 
      10.1098/rstb.1993.0068.