PMID- 8106613
OWN - NLM
STAT- MEDLINE
DCOM- 19940323
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 78
IP  - 2
DP  - 1994 Feb
TI  - The relationship between serum levels of interleukin-6 and thyroid hormone in 
      children with acute respiratory infection.
PG  - 288-91
AB  - To determine whether monocyte-derived humoral factors such as tumor necrosis 
      factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta), and IL-6 modulate serum 
      thyroid hormone levels in infectious disorders, we measured serum levels of these 
      monocyte-derived products, T3, T4, and C-reactive protein (CRP) in 59 
      out-patients with acute respiratory infection, aged 5 months to 15 yr (mean +/- 
      SD, 5.7 +/- 4.2 yr). To minimize individual variation in their clinical and 
      nutritional conditions, we selected out-patients with fever lasting for at least 
      3 days who had no severe disturbance of food intake. Serum T3 concentrations 
      tended to be low in these subjects; 3 (5.1%) had levels below 1.2 nmol/L, L, and 
      13 (22.0%) had levels below 1.5 nmol/L. Serum T3 levels in 22 patients with 
      elevated IL-6 (> 15 pg/mL) were significantly lower than those in 19 patients 
      with normal IL-6 (< or = 5 pg/mL; T3, 1.7 +/- 0.4 vs. 2.2 +/- 0.6 nmol/L; P < 
      0.05). The serum IL-6 concentration was correlated inversely with the serum T3 
      level (r = -0.324; P = 0.012) as well as the T3/T4 ratio (r = -0.279; P = 0.032). 
      Furthermore, a significant negative correlation was observed between CRP (induced 
      mainly by IL-6) and T3 (r = -0.408; P = 0.001) or the T3/T4 ratio (r = 0.302; P = 
      0.020). On the other hand, TNF alpha was measurable in only 9 of 59 patients, and 
      there was no correlation between TNF alpha and levels of thyroid hormone, CRP, or 
      IL-6. Serum IL-1 beta was weakly detected in only 1 patient. On follow-up study 
      of 10 of these patients, the serum T3 and T3/T4 ratio increased significantly 
      with a reciprocal decrease in IL-6 and CRP during convalescence. No remarkable 
      change in the serum T4 level was observed in our study. Our data suggest that the 
      euthyroid sick syndrome is relatively common in children with acute respiratory 
      infection, and IL-6 appears to mediate this syndrome in infectious disorders.
FAU - Hashimoto, H
AU  - Hashimoto H
AD  - Department of Pediatrics, Kanazawa University School of Medicine, Japan.
FAU - Igarashi, N
AU  - Igarashi N
FAU - Yachie, A
AU  - Yachie A
FAU - Miyawaki, T
AU  - Miyawaki T
FAU - Sato, T
AU  - Sato T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Acute Disease
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Interleukin-1/blood
MH  - Interleukin-6/*blood/physiology
MH  - Male
MH  - Radioimmunoassay
MH  - Respiratory Tract Infections/*blood/epidemiology
MH  - Thyroxine/*blood
MH  - Triiodothyronine/*blood
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1210/jcem.78.2.8106613 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1994 Feb;78(2):288-91. doi: 10.1210/jcem.78.2.8106613.