PMID- 8111244
OWN - NLM
STAT- MEDLINE
DCOM- 19940331
LR  - 20181016
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 103
IP  - 3
DP  - 1994
TI  - Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 
      cells.
PG  - 260-5
AB  - Overnight (10-16 h) incubation of retinoic acid (RA), a derivative of vitamin A, 
      specifically induced LTC4 synthase activity (5 to 10-fold), but not LTA4 
      hydrolase activity in the lysate of rat basophilic leukemia-1 (RBL-1) cells. A 
      time course study revealed that the increase of LTC4 synthase activity was time 
      dependent and that the peak value was obtained after a 24-hour incubation with 
      RA. The induction of enzyme activity was specifically localized to the microsomal 
      fraction. Glutathione (GSH) S-transferase activity measured by using the same 
      cell lysate as an enzyme source and 1-chloro-2,4-dinitrobenzene (DNCB) as a 
      substrate was not influenced by RA treatment, indicating that the induction by RA 
      is specific for membrane-bound LTC4 synthase. The induction of LTC4 synthase may 
      be an important regulatory mechanism of peptide-LT synthesis in allergy and 
      inflammatory diseases.
FAU - Hamasaki, Y
AU  - Hamasaki Y
AD  - Department of Pediatrics, Saga Medical School, Japan.
FAU - Abe, M
AU  - Abe M
FAU - Matsumoto, S
AU  - Matsumoto S
FAU - Ichimaru, T
AU  - Ichimaru T
FAU - Hara, N
AU  - Hara N
FAU - Miyazaki, S
AU  - Miyazaki S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 3.3.2.- (Epoxide Hydrolases)
RN  - EC 4.4.1.20 (leukotriene-C4 synthase)
RN  - V38765PUZ6 (leukotriene A4 hydrolase)
SB  - IM
MH  - Animals
MH  - Enzyme Induction/drug effects
MH  - Epoxide Hydrolases/biosynthesis
MH  - Glutathione Transferase/*biosynthesis/metabolism
MH  - Leukemia, Basophilic, Acute/*enzymology
MH  - Rats
MH  - Subcellular Fractions/enzymology
MH  - Time Factors
MH  - Tretinoin/*pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1159/000236637 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1994;103(3):260-5. doi: 10.1159/000236637.