PMID- 8114916
OWN - NLM
STAT- MEDLINE
DCOM- 19940330
LR  - 20210103
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 367
IP  - 6459
DP  - 1994 Jan 13
TI  - High-affinity IgE receptor on eosinophils is involved in defence against 
      parasites.
PG  - 183-6
AB  - Parasitic infections are often associated with eosinophilia and high levels of 
      immunoglobulin E (IgE). This observation has led to speculation that eosinophils 
      and IgE may act together in the immune response against parasites. In support of 
      this hypothesis, IgE and eosinophils participate in cytotoxic reactions directed 
      against Schistosoma mansoni larvae in vitro. Furthermore, epidemiological studies 
      have shown an inverse correlation between levels of specific IgE and rates of 
      infection with Schistosoma. The low-affinity IgE receptor (Fc epsilon RII/CD23) 
      was first incriminated in eosinophil activation. The fact that the high-affinity 
      IgE receptor (Fc epsilon RI) is not only expressed on mast cells and basophils 
      but also on Langerhans cells led us to investigate the presence of Fc epsilon RI 
      on eosinophils. Here we show that Fc epsilon RI is expressed on eosinophils from 
      hypereosinophilic patients, is involved in eosinophil degranulation, and 
      participates in eosinophil-mediated cytotoxicity against S. mansoni. Our results 
      indicate that Fc epsilon RI may play a major part in immune defence against 
      parasites.
FAU - Gounni, A S
AU  - Gounni AS
AD  - Centre d'Immunologie et de Biologie Parasitaire, Unite Mixte INSERM U167-CNRS624, 
      Institut Pasteur, Lille, France.
FAU - Lamkhioued, B
AU  - Lamkhioued B
FAU - Ochiai, K
AU  - Ochiai K
FAU - Tanaka, Y
AU  - Tanaka Y
FAU - Delaporte, E
AU  - Delaporte E
FAU - Capron, A
AU  - Capron A
FAU - Kinet, J P
AU  - Kinet JP
FAU - Capron, M
AU  - Capron M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cytotoxicity, Immunologic
MH  - Eosinophilia/immunology
MH  - Eosinophils/*immunology
MH  - Humans
MH  - Neutrophils/immunology
MH  - RNA, Messenger/blood
MH  - Receptors, IgE/analysis/*immunology
MH  - Schistosoma mansoni/*immunology
EDAT- 1994/01/13 00:00
MHDA- 1994/01/13 00:01
CRDT- 1994/01/13 00:00
PHST- 1994/01/13 00:00 [pubmed]
PHST- 1994/01/13 00:01 [medline]
PHST- 1994/01/13 00:00 [entrez]
AID - 10.1038/367183a0 [doi]
PST - ppublish
SO  - Nature. 1994 Jan 13;367(6459):183-6. doi: 10.1038/367183a0.