PMID- 8115031
OWN - NLM
STAT- MEDLINE
DCOM- 19940328
LR  - 20190914
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 25
IP  - 5
DP  - 1993 Nov
TI  - The effect of TRH on ethanol-induced sedation in alcohol-preferring and 
      -nonpreferring rats.
PG  - 283-7
AB  - TRH antagonism of ethanol sedation was evaluated in selectively-bred 
      alcohol-preferring (P) and -nonpreferring (NP) rats. Intracerebroventricular 
      (i.c.v.) infusions of TRH significantly reduced sleep time in the NP rats. In the 
      P rats, TRH tended to reduce sleep, but this reduction was not significant. TRH 
      had no significant effect on peripheral blood alcohol concentrations. The present 
      results show that NP rats are more sensitive to the analeptic effect of TRH 
      compared to P rats. These data support and extend those of others who have 
      demonstrated a TRH antagonism on drug-induced sedation. Differential sensitivity 
      to TRH may reflect differences in TRH receptor activity and/or TRH metabolism. 
      Sensitivity to TRH analepsis may be associated with sensitivity to ethanol.
FAU - Morzorati, S
AU  - Morzorati S
AD  - Department of Psychiatry, Indiana University School of Medicine, Indianapolis 
      46202.
FAU - Kubek, M J
AU  - Kubek MJ
LA  - eng
GR  - AA07611/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 3K9958V90M (Ethanol)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Choice Behavior/*physiology
MH  - Ethanol/*antagonists & inhibitors
MH  - Male
MH  - Rats
MH  - Sleep/*drug effects
MH  - Thyrotropin-Releasing Hormone/*pharmacology
EDAT- 1993/11/01 00:00
MHDA- 1993/11/01 00:01
CRDT- 1993/11/01 00:00
PHST- 1993/11/01 00:00 [pubmed]
PHST- 1993/11/01 00:01 [medline]
PHST- 1993/11/01 00:00 [entrez]
AID - 0143-4179(93)90045-C [pii]
AID - 10.1016/0143-4179(93)90045-c [doi]
PST - ppublish
SO  - Neuropeptides. 1993 Nov;25(5):283-7. doi: 10.1016/0143-4179(93)90045-c.