PMID- 8115425
OWN - NLM
STAT- MEDLINE
DCOM- 19940325
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 47
IP  - 1
DP  - 1994 Jan
TI  - Barrel rotation induced by central arginine8-vasopressin treatment: involvement 
      of neurohypophyseal peptide receptors.
PG  - 27-32
AB  - Two series of experiments were done to investigate the mechanism underlying 
      arginine8-vasopressin (AVP)-induced barrel rotation in rats. In the first series, 
      the effect of intracerebroventricular (ICV) administration of various 
      neurohypophyseal hormone antagonists on AVP-induced barrel rotation was studied. 
      The more vasopressin was given, the more the rats exhibited barrel rotation. ICV 
      pretreatment with a V1 vasopressin receptor antagonist, d(CH2)5[Tyr(Me)2]AVP, 
      prevented barrel rotation, while similar treatment with a V2-antagonist, 
      d(CH2)5[dIle2Ile4]AVP, did not affect vasopressin-induced barrel rotation. 
      However, Des-Gly,NH2d(CH2)5[Tyr)Me2)Thr4Orn8]-vasotocin, a specific oxytocin 
      antagonist, potentiated the effect of AVP on barrel rotation. The second 
      experiment was performed in rats equipped with a telemetry system to measure 
      heart rate (HR), core temperature (CT), and gross locomotor activity. Also, in 
      this experiment the incidence of AVP-induced barrel rotation was dose-dependent, 
      as was the number of rats that died. Barrel rotation was accompanied by a 
      significant decrease in CT and HR, while rats that did not develop hypothermia 
      did not show barrel rotation. These results suggest that a V1 receptor is 
      involved in barrel rotation. Since AVP-induced hypothermia is also mediated by a 
      V1 receptor, it is postulated that hypothermia is a prerequisite for barrel 
      rotation to occur. Further experiments are needed to substantiate this 
      hypothesis.
FAU - Diamant, M
AU  - Diamant M
AD  - Rudolf Magnus Institute, Utrecht University, The Netherlands.
FAU - Baars, A M
AU  - Baars AM
FAU - Kovacs, G L
AU  - Kovacs GL
FAU - De Wied, D
AU  - De Wied D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Neuropeptides)
RN  - 0 (Receptors, Pituitary Hormone)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/administration & dosage/*pharmacology
MH  - Body Temperature/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuropeptides/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Pituitary Hormone/*drug effects
MH  - Stereotyped Behavior/*drug effects
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0091-3057(94)90107-4 [pii]
AID - 10.1016/0091-3057(94)90107-4 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Jan;47(1):27-32. doi: 10.1016/0091-3057(94)90107-4.