PMID- 8116799
OWN - NLM
STAT- MEDLINE
DCOM- 19940325
LR  - 20190821
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 18
IP  - 3
DP  - 1994 Mar
TI  - Glycogen-rich clear cell rhabdomyosarcoma of the mediastinum. Potential 
      diagnostic pitfall.
PG  - 302-8
AB  - A 63-year-old black man of Caribbean origin, seropositive for human T-cell 
      lymphoma virus type I (HTLV-I), presented with a 4-week history of progressive 
      dyspnea, and was found to have a tumor of the anterior mediastinum. Incisional 
      biopsy revealed a malignant neoplasm with a solid pattern of glycogen-rich clear 
      cells. Diffuse expression of vimentin was observed, whereas only rare cells were 
      immunoreactive for muscle-specific actin and desmin. Ultrastructure revealed a 
      large amount of mono-particulate glycogen in most cells and features of 
      rhabdomyogenic differentiation in occasional cells. The autopsy revealed a 23 x 
      14-cm (1,345 g), soft and white mediastinal neoplasm bulging in the right thorax 
      with right pleural metastases. HTLV-1 proviral genome was not detected within 
      tumor cells by polymerase chain reaction. This rhabdomyosarcoma is best 
      classified as the solid subtype of the alveolar variant, with an unusually large 
      amount of cytoplasmic glycogen. Clear cell rhabdomyosarcoma could be potentially 
      confused with more commonly encountered clear cell tumors, particularly in the 
      mediastinum.
FAU - Begin, L R
AU  - Begin LR
AD  - Department of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, 
      Quebec, Canada.
FAU - Schurch, W
AU  - Schurch W
FAU - Lacoste, J
AU  - Lacoste J
FAU - Hiscott, J
AU  - Hiscott J
FAU - Melnychuk, D A
AU  - Melnychuk DA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Cytoplasm/metabolism
MH  - Diagnosis, Differential
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Mediastinal Neoplasms/*diagnosis/metabolism/pathology
MH  - Middle Aged
MH  - Rhabdomyosarcoma/*diagnosis/metabolism/pathology
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1097/00000478-199403000-00011 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 1994 Mar;18(3):302-8. doi: 10.1097/00000478-199403000-00011.