PMID- 8116838
OWN - NLM
STAT- MEDLINE
DCOM- 19940331
LR  - 20190825
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 17
IP  - 6
DP  - 1993 Dec
TI  - Alterations in activity following alcohol administration during the third 
      trimester equivalent in P and NP rats.
PG  - 1240-6
AB  - There is considerable variation in the consequences of alcohol abuse during 
      pregnancy on infant outcome. Although it is clear that a number of factors 
      contribute to this variability, one hypothesis that has received recent attention 
      is the role of genetic differences in response to alcohol. This study examined 
      activity levels in the alcohol-preferring (P) and alcohol-nonpreferring (NP) rats 
      following neonatal alcohol exposure. Although these lines were selectively bred 
      for differences in voluntary alcohol consumption, they also differ in their 
      sensitivity and tolerance to alcohol. The P and NP offspring were artificially 
      reared and administered ethanol (either 6 or 4 g/kg/day) from postnatal day 4 (PN 
      4) until PN 10 via intragastric cannula. An artificially reared isocaloric 
      maltose group and a normally reared control group were also included. From PN 18 
      to PN 21, subjects were tested daily for 30 min in an automated activity monitor. 
      Exposure to either the 4 or 6 g/kg dose of ethanol resulted in overactivity in P 
      rats. However, only the 6 g/kg dose group displayed overactivity among the NP 
      offspring. Furthermore, the level of overactivity displayed by the 
      alcohol-exposed P rats was significantly greater than that displayed by the 
      alcohol-exposed NP rats. These data suggest that genetic differences in response 
      to alcohol may be a predictor for the behavioral teratogenic effects of alcohol.
FAU - Riley, E P
AU  - Riley EP
AD  - Center for Behavioral Teratology, San Diego State University, CA 92120.
FAU - Barron, S
AU  - Barron S
FAU - Melcer, T
AU  - Melcer T
FAU - Gonzalez, D
AU  - Gonzalez D
LA  - eng
GR  - AA06902/AA/NIAAA NIH HHS/United States
GR  - AA07611/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/*genetics/physiopathology
MH  - Animals
MH  - Body Weight/drug effects/genetics/physiology
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*toxicity
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*genetics/physiopathology
MH  - Male
MH  - Motor Activity/*drug effects/physiology
MH  - Phenotype
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
AID - 10.1111/j.1530-0277.1993.tb05236.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 1993 Dec;17(6):1240-6. doi: 
      10.1111/j.1530-0277.1993.tb05236.x.